dc.contributor.author |
Morey, Rajendra A |
|
dc.contributor.author |
Haswell, Courtney C |
|
dc.contributor.author |
Selgrade, Elizabeth S |
|
dc.contributor.author |
Massoglia, Dino |
|
dc.contributor.author |
Liu, Chunlei |
|
dc.contributor.author |
Weiner, Jonathan |
|
dc.contributor.author |
Marx, Christine E |
|
dc.contributor.author |
MIRECC Work Group |
|
dc.contributor.author |
Cernak, Ibolja |
|
dc.contributor.author |
McCarthy, Gregory |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2015-12-03T15:31:08Z |
|
dc.date.issued |
2013-11 |
|
dc.identifier |
http://www.ncbi.nlm.nih.gov/pubmed/22706988 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/10985 |
|
dc.description.abstract |
Mild traumatic brain injury (TBI) is a common source of morbidity from the wars in
Iraq and Afghanistan. With no overt lesions on structural MRI, diagnosis of chronic
mild TBI in military veterans relies on obtaining an accurate history and assessment
of behavioral symptoms that are also associated with frequent comorbid disorders,
particularly posttraumatic stress disorder (PTSD) and depression. Military veterans
from Iraq and Afghanistan with mild TBI (n = 30) with comorbid PTSD and depression
and non-TBI participants from primary (n = 42) and confirmatory (n = 28) control groups
were assessed with high angular resolution diffusion imaging (HARDI). White matter-specific
registration followed by whole-brain voxelwise analysis of crossing fibers provided
separate partial volume fractions reflecting the integrity of primary fibers and secondary
(crossing) fibers. Loss of white matter integrity in primary fibers (P < 0.05; corrected)
was associated with chronic mild TBI in a widely distributed pattern of major fiber
bundles and smaller peripheral tracts including the corpus callosum (genu, body, and
splenium), forceps minor, forceps major, superior and posterior corona radiata, internal
capsule, superior longitudinal fasciculus, and others. Distributed loss of white matter
integrity correlated with duration of loss of consciousness and most notably with
"feeling dazed or confused," but not diagnosis of PTSD or depressive symptoms. This
widespread spatial extent of white matter damage has typically been reported in moderate
to severe TBI. The diffuse loss of white matter integrity appears consistent with
systemic mechanisms of damage shared by blast- and impact-related mild TBI that involves
a cascade of inflammatory and neurochemical events.
|
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartof |
Hum Brain Mapp |
|
dc.relation.isversionof |
10.1002/hbm.22117 |
|
dc.subject |
crossing fibers |
|
dc.subject |
high angular resolution diffusion imaging |
|
dc.subject |
mild traumatic brain injury |
|
dc.subject |
posttraumatic stress disorder |
|
dc.subject |
white matter |
|
dc.subject |
Adolescent |
|
dc.subject |
Adult |
|
dc.subject |
Afghan Campaign 2001- |
|
dc.subject |
Aged |
|
dc.subject |
Brain |
|
dc.subject |
Brain Injuries |
|
dc.subject |
Brain Mapping |
|
dc.subject |
Diffusion Tensor Imaging |
|
dc.subject |
Female |
|
dc.subject |
Humans |
|
dc.subject |
Image Processing, Computer-Assisted |
|
dc.subject |
Iraq War, 2003-2011 |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Nerve Fibers |
|
dc.subject |
Neuropsychological Tests |
|
dc.subject |
Regression Analysis |
|
dc.subject |
Stress Disorders, Post-Traumatic |
|
dc.subject |
Unconsciousness |
|
dc.subject |
Veterans |
|
dc.subject |
Young Adult |
|
dc.title |
Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and
Afghanistan war veterans.
|
|
dc.type |
Journal article |
|
duke.contributor.id |
Morey, Rajendra A|0288586 |
|
duke.contributor.id |
Liu, Chunlei|0253269 |
|
duke.contributor.id |
Marx, Christine E|0062021 |
|
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/22706988 |
|
pubs.begin-page |
2986 |
|
pubs.end-page |
2999 |
|
pubs.issue |
11 |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Institute for Brain Sciences |
|
pubs.organisational-group |
Duke-UNC Center for Brain Imaging and Analysis |
|
pubs.organisational-group |
Faculty |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Institutes and Provost's Academic Units |
|
pubs.organisational-group |
Psychiatry & Behavioral Sciences |
|
pubs.organisational-group |
Psychiatry & Behavioral Sciences, Translational Neuroscience |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
University Institutes and Centers |
|
pubs.publication-status |
Published |
|
pubs.volume |
34 |
|
dc.identifier.eissn |
1097-0193 |
|