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Isolated Noncompaction of the Left Ventricle in Adults.

dc.contributor.author Collier, P
dc.contributor.author Hussein, A
dc.contributor.author Karimianpour, A
dc.contributor.author Krasuski, Richard Andrew
dc.coverage.spatial United States
dc.date.accessioned 2015-12-03T15:32:37Z
dc.date.issued 2015-08-04
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26227197
dc.identifier S0735-1097(15)02780-1
dc.identifier.uri http://hdl.handle.net/10161/10986
dc.description.abstract Isolated left ventricular noncompaction (ILVNC) is a cardiomyopathy that was first described in 1926 as a "spongy myocardium." The disorder results from intrauterine arrest of compaction of the loose interwoven meshwork of the fetal myocardial primordium and subsequent persistence of deep trabecular recesses in the myocardial wall. The classical clinical presentation is a triad of heart failure, arrhythmias, and embolic events from mural thrombi. ILVNC has been associated with several autosomal dominant, X-linked, and mitochondrial genetic mutations that are also shared among other cardiomyopathies. Over the past decade, ILVNC has been subject to intensive research, as it increases the risk for sudden cardiac death. This review focuses on the current understanding of ILVNC in adult populations and attempts to provide organized insight into the disease process, screening, diagnosis, management, role of device therapy, and prognosis.
dc.language eng
dc.relation.ispartof J Am Coll Cardiol
dc.relation.isversionof 10.1016/j.jacc.2015.06.017
dc.subject LVNC
dc.subject congenital
dc.subject heart failure
dc.subject primordial
dc.subject Adult
dc.subject Death, Sudden, Cardiac
dc.subject Defibrillators, Implantable
dc.subject Disease Management
dc.subject Disease Progression
dc.subject Humans
dc.subject Isolated Noncompaction of the Ventricular Myocardium
dc.subject Prognosis
dc.title Isolated Noncompaction of the Left Ventricle in Adults.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26227197
pubs.begin-page 578
pubs.end-page 585
pubs.issue 5
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 66
dc.identifier.eissn 1558-3597


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