Show simple item record

Effect of obesity on B-type natriuretic peptide levels in patients with pulmonary arterial hypertension.

dc.contributor.author Batal, O
dc.contributor.author Dweik, RA
dc.contributor.author Faulx, M
dc.contributor.author Hammel, JP
dc.contributor.author Hussein, AA
dc.contributor.author Khatib, OF
dc.contributor.author Krasuski, Richard Andrew
dc.contributor.author Minai, OA
dc.coverage.spatial United States
dc.date.accessioned 2015-12-03T17:26:09Z
dc.date.issued 2012-09-15
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/22683040
dc.identifier S0002-9149(12)01352-5
dc.identifier.uri http://hdl.handle.net/10161/11000
dc.description.abstract Brain natriuretic peptide (BNP) levels are lower in obese patients with left ventricular failure than in their comparably ill, leaner counterparts. The effect of obesity on BNP in patients with pulmonary arterial hypertension (PAH) is unknown. We reviewed our prospective PAH registry data collected from November 2001 to December 2007 for patients undergoing right heart catheterization who met the criteria for PAH and had the BNP level and body mass index determined at baseline. The median BNP level for the lean, overweight, and obese patients was 285 pg/ml (interquartile range 131 to 548), 315 pg/ml (interquartile range 88 to 531), and 117 pg/ml (interquartile range 58 to 270), respectively (p = 0.029). A greater body mass index was associated with a lower BNP level, adjusted for age, gender, New York Heart Association functional class, hypertension, coronary artery disease, and mean right atrial and pulmonary arterial pressures (p <0.001). No statistically significant differences were found among the groups in age, race, medical co-morbidities, underlying etiology of PAH, use of vasoactive medications, New York Heart Association functional class, echocardiographic parameters, or pulmonary function. Obese patients had greater right atrial and pulmonary artery pressures. Increased BNP was associated with worse survival in the lean and overweight patients only. In conclusion, the BNP levels are attenuated in obese patients with PAH despite similar or worse hemodynamics or functional class compared to lean or overweight patients and should therefore be interpreted with caution.
dc.language eng
dc.relation.ispartof Am J Cardiol
dc.relation.isversionof 10.1016/j.amjcard.2012.05.017
dc.subject Body Mass Index
dc.subject Cardiac Catheterization
dc.subject Echocardiography
dc.subject Familial Primary Pulmonary Hypertension
dc.subject Female
dc.subject Follow-Up Studies
dc.subject Humans
dc.subject Hypertension, Pulmonary
dc.subject Male
dc.subject Middle Aged
dc.subject Natriuretic Peptide, Brain
dc.subject Obesity
dc.subject Overweight
dc.subject Prospective Studies
dc.subject Survival Analysis
dc.subject Thinness
dc.title Effect of obesity on B-type natriuretic peptide levels in patients with pulmonary arterial hypertension.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/22683040
pubs.begin-page 909
pubs.end-page 914
pubs.issue 6
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 110
dc.identifier.eissn 1879-1913


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record