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Pulmonary vein isolation for the treatment of drug-refractory atrial fibrillation in adults with congenital heart disease.

dc.contributor.author Agarwal, S
dc.contributor.author Krasuski, Richard Andrew
dc.contributor.author Muhammad, KI
dc.contributor.author Natale, A
dc.contributor.author Philip, F
dc.coverage.spatial United States
dc.date.accessioned 2015-12-03T17:38:06Z
dc.date.issued 2012-07
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/22469422
dc.identifier.uri http://hdl.handle.net/10161/11013
dc.description.abstract BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia in adults with congenital heart disease (CHD). Long-term antiarrhythmic therapy (AAT) in these patients has significant shortcomings. The safety and efficacy of pulmonary vein antrum isolation (PVAI) for the treatment of AF in CHD is presently unknown. HYPOTHESIS: We hypothesized that PVAI for AF in patients with CHD is effective and safe. METHODS: We reviewed a prospective cohort of 4315 patients (age ≥ 18) undergoing PVAI for drug refractory AF at a single institution and identified 36 consecutive patients with CHD (single ventricle physiology, tetralogy of Fallot, coarctation of the aorta, ventricular septal defects, atrial septal defects (ASD) and cardiomyopathy resulting from anomalous origin of the left main coronary from the pulmonary artery). A second cohort of 355 consecutive patients with noncongenital structural heart disease (NSHD) (coronary artery disease, valvular heart disease, ejection fraction <50%, or prior noncongenital cardiac surgery) undergoing PVAI during the same time period was used as a control. Success was defined as freedom from AF starting two months after PVAI in the absence AAT until the end of follow-up. Partial success was defined as freedom from AF in the presence of AAT until the end of follow-up. Combined success was defined as the sum of success and partial success. We compared the outcomes with the use of propensity-score matching in the overall cohort. RESULTS: Patients with NSHD were older and had higher prevalence of hypertension (P < .01), diabetes (P < .01) and hyperlipidemia (P < .01). The most common CHD lesion was ASD (61%) and the most common NSHD lesion was valvular heart disease (57%). After one PVAI, success was achieved in 42% and 53% at 300 days in the CHD and NSHD groups respectively. Four-year success was achieved in 27% and 36% in the CHD and NSHD groups, respectively. There were no significant differences in the success rates between patients groups (P= .46), nor were there any differences in left atrial size or changes in ejection fraction after one or two PVAI in the respective groups. Complication rates between the CHD and NSHD groups were similar (15% vs. 11%, P= .42) except for a higher risk of vascular site complications in patients with CHD (8% vs. 1%, P < .05). CONCLUSION: PVAI is an attractive treatment modality in drug refractory AF in CHD, with combined success rates in excess of 60%. The maintenance of sinus rhythm after PVAI in CHD appears similar to that of NSHD and warrants prospective validation.
dc.language eng
dc.relation.ispartof Congenit Heart Dis
dc.relation.isversionof 10.1111/j.1747-0803.2012.00649.x
dc.subject Atrial Fibrillation
dc.subject Cardiac Surgical Procedures
dc.subject Female
dc.subject Heart Diseases
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Pulmonary Veins
dc.subject Retrospective Studies
dc.subject Treatment Failure
dc.title Pulmonary vein isolation for the treatment of drug-refractory atrial fibrillation in adults with congenital heart disease.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/22469422
pubs.begin-page 392
pubs.end-page 399
pubs.issue 4
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 7
dc.identifier.eissn 1747-0803


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