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Association of anemia and long-term survival in patients with pulmonary hypertension.

dc.contributor.author Krasuski, Richard A
dc.contributor.author Hart, Stephen A
dc.contributor.author Smith, Brad
dc.contributor.author Wang, Andrew
dc.contributor.author Harrison, J Kevin
dc.contributor.author Bashore, Thomas M
dc.coverage.spatial Netherlands
dc.date.accessioned 2015-12-03T17:48:19Z
dc.date.issued 2011-08-04
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20472313
dc.identifier S0167-5273(10)00269-X
dc.identifier.uri https://hdl.handle.net/10161/11027
dc.description.abstract BACKGROUND: Anemia is a marker of worsened clinical outcome in patients with heart failure from left ventricular dysfunction. Pulmonary hypertension often results in right ventricular dysfunction. Accordingly we sought to examine the association of hemoglobin levels and long-term all-cause mortality in a cohort of patients with pulmonary hypertension. METHODS: Baseline demographic information, clinical characteristics and fasting blood work were obtained in a cohort of 145 patients with pulmonary hypertension referred for pulmonary vasodilator testing. Data was retrospectively analyzed with Cox-proportional hazards analysis. RESULTS: Baseline characteristics of the cohort included age (mean±SD) 55.8±14.6 years, 75% women, 50% with idiopathic pulmonary hypertension, mean pulmonary artery pressure 46.1±14.2 mm Hg and arterial O(2) saturation 91±6 %. The most commonly utilized pulmonary hypertension specific therapeutic agents in descending order of frequency were epoprostenol (27%), sildenafil (21%), bosentan (17%), and treprostinil (6%). Over a median follow-up of 2.1 years, there were 39 deaths (26.9%). Patients who died had significantly lower hemoglobin levels than those survived (12.2±2.3 vs. 13.7±2.0, p<0.001). After adjustment for known predictors of death and pulmonary hypertension etiology, anemic patients were 3.3 times more likely to die than non-anemic patients (95% CI [1.43-7.51], p=0.005). CONCLUSIONS: Hemoglobin levels closely parallel survival in pulmonary hypertension. Modification of anemia in this disorder could alter the clinical course and calls for further research in this area.
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartof Int J Cardiol
dc.relation.isversionof 10.1016/j.ijcard.2010.04.038
dc.subject Adult
dc.subject Aged
dc.subject Anemia
dc.subject Cohort Studies
dc.subject Female
dc.subject Follow-Up Studies
dc.subject Hemoglobins
dc.subject Humans
dc.subject Hypertension, Pulmonary
dc.subject Male
dc.subject Middle Aged
dc.subject Retrospective Studies
dc.subject Survival Rate
dc.subject Survivors
dc.title Association of anemia and long-term survival in patients with pulmonary hypertension.
dc.type Journal article
duke.contributor.id Krasuski, Richard A|0199150
duke.contributor.id Wang, Andrew|0028746
duke.contributor.id Harrison, J Kevin|0011559
duke.contributor.id Bashore, Thomas M|0112850
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20472313
pubs.begin-page 291
pubs.end-page 295
pubs.issue 3
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 150
dc.identifier.eissn 1874-1754
duke.contributor.orcid Krasuski, Richard A|0000-0003-3150-5215
duke.contributor.orcid Wang, Andrew|0000-0001-8729-0933


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