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Impact of fibrinogen levels on angiographic progression and 12-year survival in the armed forces regression study.

dc.contributor.author Devendra, Ganesh P
dc.contributor.author Hart, Stephen A
dc.contributor.author Krasuski, Richard Andrew
dc.contributor.author Whitney, EJ
dc.coverage.spatial United States
dc.date.accessioned 2015-12-03T18:03:29Z
dc.date.issued 2010-05
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20304867
dc.identifier 0003319709360525
dc.identifier.uri http://hdl.handle.net/10161/11041
dc.description.abstract We assessed the role of fibrinogen levels on angiographic progression and long-term survival among 111 patients with coronary disease enrolled in the Armed Forces Regression Study (AFREGS). Baseline fibrinogen levels and quantitative coronary angiography were performed initially and at 30 months. Progression or nonregression of coronary disease was more prevalent in patients with high fibrinogen than patients with normal fibrinogen (66.1% vs 45.5%; P = .022). Twelve-year cardiovascular (CV) mortality was substantially higher if fibrinogen was elevated (17.9% vs 3.6%, P = .016). Among patients with elevated fibrinogen and angiographic progression or nonregression, there were 10 deaths and all were CV. Elevated levels of fibrinogen predict the angiographic progression of existing coronary disease and likelihood of CV death. Among patients with elevated levels of fibrinogen, angiographic progression identifies a significantly increased likelihood of a fatal CV event.
dc.language eng
dc.relation.ispartof Angiology
dc.relation.isversionof 10.1177/0003319709360525
dc.subject Aged
dc.subject Coronary Angiography
dc.subject Coronary Artery Disease
dc.subject Double-Blind Method
dc.subject Female
dc.subject Fibrinogen
dc.subject Follow-Up Studies
dc.subject Humans
dc.subject Logistic Models
dc.subject Male
dc.subject Middle Aged
dc.subject Military Personnel
dc.subject Predictive Value of Tests
dc.subject Risk Factors
dc.subject Survival Rate
dc.title Impact of fibrinogen levels on angiographic progression and 12-year survival in the armed forces regression study.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20304867
pubs.begin-page 333
pubs.end-page 337
pubs.issue 4
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 61
dc.identifier.eissn 1940-1574


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