Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
Abstract
The biodistribution of no-carrier-added (n.c.a.) meta-[131I]iodobenzylguanidine ([131I]MIBG)
and that prepared by the standard isotopic exchange method were compared in athymic
mice bearing SK-N-SH human neuroblastoma xenografts. No advantage in tumour uptake
was observed for the n.c.a. preparation. BALB/c nu/nu mice exhibited lower uptake
in highly innervated normal tissues (heart and adrenals) than normal BALB/c mice.
In another experiment, the distribution of n.c.a. [131I]MIBG in the absence or presence
(3-9 micrograms) of MIBG carrier was determined. At both 4 h and 24 h, the heart uptake
was reduced by a factor of 1.5 even at a dose of 3 micrograms MIBG. Tumour uptake
was not significantly altered by various amounts of unlabelled MIBG at either time
point.
Type
Journal articleSubject
3-IodobenzylguanidineAnimals
Antineoplastic Agents
Humans
Iodobenzenes
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Transplantation
Neoplasms, Experimental
Neuroblastoma
Tissue Distribution
Transplantation, Heterologous
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Henry Seth Friedman
James B. Powell, Jr. Distinguished Professor of Pediatric Oncology, in the School
of Medicine
Overview: Our laboratory is pursuing a comprehensive analysis of the biology and
therapy of adult and childhood central nervous system malignancies, particularly high-grade
medulloblastoma, glioma, and ependymoma. Laboratory Studies: Active programs,
using human adult and pediatric CNS tumor continuous cell lines, transplantable xenografts
growing subcutaneously and intracranially in athymic nude mice and rats, and as well
as in the subarachnoid space of the ath
Stephen Thomas Keir
Professor in Neurosurgery
Brain Tumors, Preclinical Testing, Translational Research
Ganesan Vaidyanathan
Professor Emeritus in Radiology
Dr. Vaidyanathan is a professor in the Department of Radiology. He is a member of
the Nuclear Medicine track of the Medical Physics Graduate Program. His research
involves development of radiopharmaceuticals especially for oncologic applications.
Some of the projects he is involved in are given below.
I. New methods of radiohalogenating antibodies and its variants a) Development
of ne
Michael Rod Zalutsky
Jonathan Spicehandler, M.D. Distinguished Professor of Neuro Oncology, in the School
of Medicine
The overall objective of our laboratory is the development of novel radioactive compounds
for improving the diagnosis and treatment of cancer. This work primarily involves
radiohalo-genation of biomolecules via site-specific approaches, generally via demetallation
reactions. Radionuclides utilized for imaging include I-123, I-124 and F-18, the later
two being of particular interest because they can be used for the quantification of
biochemical and physiological processes in the living huma
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