Show simple item record

A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis.

dc.contributor.author Ribeiro, Ângela M
dc.contributor.author Zepeda-Mendoza, M Lisandra
dc.contributor.author Bertelsen, Mads F
dc.contributor.author Kristensen, Annemarie T
dc.contributor.author Jarvis, Erich D
dc.contributor.author Gilbert, M Thomas P
dc.contributor.author da Fonseca, Rute R
dc.coverage.spatial England
dc.date.accessioned 2015-12-08T03:57:36Z
dc.date.issued 2015-06-30
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26123414
dc.identifier 10.1186/s12862-015-0409-y
dc.identifier.uri https://hdl.handle.net/10161/11124
dc.description.abstract BACKGROUND: Hemostasis is a defense mechanism that enhances an organism's survival by minimizing blood loss upon vascular injury. In vertebrates, hemostasis has been evolving with the cardio-vascular and hemodynamic systems over the last 450 million years. Birds and mammals have very similar vascular and hemodynamic systems, thus the mechanism that blocks ruptures in the vasculature is expected to be the same. However, the speed of the process varies across vertebrates, and is particularly slow for birds. Understanding the differences in the hemostasis pathway between birds and mammals, and placing them in perspective to other vertebrates may provide clues to the genetic contribution to variation in blood clotting phenotype in vertebrates. We compiled genomic data corresponding to key elements involved in hemostasis across vertebrates to investigate its genetic basis and understand how it affects fitness. RESULTS: We found that: i) fewer genes are involved in hemostasis in birds compared to mammals; and ii) the largest differences concern platelet membrane receptors and components from the kallikrein-kinin system. We propose that lack of the cytoplasmic domain of the GPIb receptor subunit alpha could be a strong contributor to the prolonged bleeding phenotype in birds. Combined analysis of laboratory assessments of avian hemostasis with the first avian phylogeny based on genomic-scale data revealed that differences in hemostasis within birds are not explained by phylogenetic relationships, but more so by genetic variation underlying components of the hemostatic process, suggestive of natural selection. CONCLUSIONS: This work adds to our understanding of the evolution of hemostasis in vertebrates. The overlap with the inflammation, complement and renin-angiotensin (blood pressure regulation) pathways is a potential driver of rapid molecular evolution in the hemostasis network. Comparisons between avian species and mammals allowed us to hypothesize that the observed mammalian innovations might have contributed to the diversification of mammals that give birth to live young.
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof BMC Evol Biol
dc.relation.isversionof 10.1186/s12862-015-0409-y
dc.subject Animals
dc.subject Biological Evolution
dc.subject Birds
dc.subject Blood Coagulation Factors
dc.subject Evolution, Molecular
dc.subject Genetic Variation
dc.subject Hemostasis
dc.subject Phylogeny
dc.subject Selection, Genetic
dc.subject Vertebrates
dc.title A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis.
dc.type Journal article
duke.contributor.id Jarvis, Erich D|0205264
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26123414
pubs.begin-page 124
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published online
pubs.volume 15
dc.identifier.eissn 1471-2148


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record