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Basal ganglia function, stuttering, sequencing, and repair in adult songbirds.

dc.contributor.author Kubikova, Lubica
dc.contributor.author Bosikova, Eva
dc.contributor.author Cvikova, Martina
dc.contributor.author Lukacova, Kristina
dc.contributor.author Scharff, Constance
dc.contributor.author Jarvis, Erich D
dc.coverage.spatial England
dc.date.accessioned 2015-12-11T01:30:24Z
dc.date.issued 2014-10-13
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/25307086
dc.identifier srep06590
dc.identifier.uri https://hdl.handle.net/10161/11142
dc.description.abstract A pallial-basal-ganglia-thalamic-pallial loop in songbirds is involved in vocal motor learning. Damage to its basal ganglia part, Area X, in adult zebra finches has been noted to have no strong effects on song and its function is unclear. Here we report that neurotoxic damage to adult Area X induced changes in singing tempo and global syllable sequencing in all animals, and considerably increased syllable repetition in birds whose song motifs ended with minor repetitions before lesioning. This stuttering-like behavior started at one month, and improved over six months. Unexpectedly, the lesioned region showed considerable recovery, including immigration of newly generated or repaired neurons that became active during singing. The timing of the recovery and stuttering suggest that immature recovering activity of the circuit might be associated with stuttering. These findings indicate that even after juvenile learning is complete, the adult striatum plays a role in higher level organization of learned vocalizations.
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof Sci Rep
dc.relation.isversionof 10.1038/srep06590
dc.subject Animals
dc.subject Basal Ganglia
dc.subject Cerebral Cortex
dc.subject Learning
dc.subject Neurons
dc.subject Songbirds
dc.subject Vocalization, Animal
dc.title Basal ganglia function, stuttering, sequencing, and repair in adult songbirds.
dc.type Journal article
duke.contributor.id Jarvis, Erich D|0205264
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/25307086
pubs.begin-page 6590
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published online
pubs.volume 4
dc.identifier.eissn 2045-2322


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