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Complex evolutionary trajectories of sex chromosomes across bird taxa.

dc.contributor.author An, N
dc.contributor.author Bachtrog, D
dc.contributor.author Gilbert, M Thomas P
dc.contributor.author Huang, Q
dc.contributor.author Jarvis, Erich David
dc.contributor.author Zhang, G
dc.contributor.author Zhang, J
dc.contributor.author Zhou, Q
dc.coverage.spatial United States
dc.date.accessioned 2015-12-11T01:49:46Z
dc.date.issued 2014-12-12
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/25504727
dc.identifier 346/6215/1246338
dc.identifier.uri https://hdl.handle.net/10161/11148
dc.description.abstract Sex-specific chromosomes, like the W of most female birds and the Y of male mammals, usually have lost most genes owing to a lack of recombination. We analyze newly available genomes of 17 bird species representing the avian phylogenetic range, and find that more than half of them do not have as fully degenerated W chromosomes as that of chicken. We show that avian sex chromosomes harbor tremendous diversity among species in their composition of pseudoautosomal regions and degree of Z/W differentiation. Punctuated events of shared or lineage-specific recombination suppression have produced a gradient of "evolutionary strata" along the Z chromosome, which initiates from the putative avian sex-determining gene DMRT1 and ends at the pseudoautosomal region. W-linked genes are subject to ongoing functional decay after recombination was suppressed, and the tempo of degeneration slows down in older strata. Overall, we unveil a complex history of avian sex chromosome evolution.
dc.language eng
dc.relation.ispartof Science
dc.relation.isversionof 10.1126/science.1246338
dc.subject Animals
dc.subject Avian Proteins
dc.subject Biological Evolution
dc.subject Birds
dc.subject Chickens
dc.subject Chromosome Inversion
dc.subject Chromosome Mapping
dc.subject Evolution, Molecular
dc.subject Female
dc.subject Male
dc.subject Phylogeny
dc.subject Recombination, Genetic
dc.subject Sex Chromosomes
dc.subject Species Specificity
dc.subject Struthioniformes
dc.subject Synteny
dc.subject Transcription Factors
dc.title Complex evolutionary trajectories of sex chromosomes across bird taxa.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/25504727
pubs.begin-page 1246338
pubs.issue 6215
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 346
dc.identifier.eissn 1095-9203


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