Convergent transcriptional specializations in the brains of humans and song-learning birds.
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Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in specific song and speech brain regions of avian vocal learners and humans. The strongest shared profiles relate bird motor and striatal song-learning nuclei, respectively, with human laryngeal motor cortex and parts of the striatum that control speech production and learning. Most of the associated genes function in motor control and brain connectivity. Thus, convergent behavior and neural connectivity for a complex trait are associated with convergent specialized expression of multiple genes.
Gene Expression Regulation
Published Version (Please cite this version)10.1126/science.1256846
Publication InfoPfenning, Andreas R; Hara, Erina; Whitney, Osceola; Rivas, Miriam V; Wang, Rui; Roulhac, Petra L; ... Jarvis, Erich D (2014). Convergent transcriptional specializations in the brains of humans and song-learning birds. Science, 346(6215). pp. 1256846. 10.1126/science.1256846. Retrieved from https://hdl.handle.net/10161/11149.
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Professor in the Department of Computer Science
Computational biology, machine learning, Bayesian statistics, transcriptional regulation, genomics and epigenomics, graphical models, Bayesian networks, hidden Markov models, systems biology, computational neurobiology, classification, feature selection
Adjunct Professor in the Dept. of Neurobiology
Dr. Jarvis' laboratory studies the neurobiology of vocal communication. Emphasis is placed on the molecular pathways involved in the perception and production of learned vocalizations. They use an integrative approach that combines behavioral, anatomical, electrophysiological and molecular biological techniques. The main animal model used is songbirds, one of the few vertebrate groups that evolved the ability to learn vocalizations. The generality of the discoveries is tested in other vocal
Associate Professor in Medicine
Assistant Research Professor of Cell Biology
Assistant Research Professor of Pharmacology & Cancer Biology
Dr. Thompson's research focuses on the development and deployment of proteomics and metabolomics mass spectrometry techniques for the analysis of biological systems. He is the Assistant Director of the Proteomics and Metabolomics Shared Resource in the Duke School of Medicine. In this role, he enjoys utilizing mass spectrometry 'omics techniques in research collaborations with investigators throughout the Duke community.
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