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Human endotoxin administration as an experimental model in drug development.
Abstract
Linking human physiology to inflammatory mechanisms discovered in vitro or in animal
models is essential to determine their importance. Innate immunity underlies many
of these inflammatory responses in health and disease. Bacterial endotoxin is the
quintessential trigger of innate immune responses. When administered to humans, endotoxin
has been an important means of demonstrating key inflammatory mechanisms in vivo.
Furthermore, endotoxin challenges have provided opportunities to test the effects
of novel inflammation-modifying agents in humans.
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Journal articlePermalink
https://hdl.handle.net/10161/11171Published Version (Please cite this version)
10.1038/clpt.2014.146Publication Info
(2014). Human endotoxin administration as an experimental model in drug development. Clin Pharmacol Ther, 96(4). pp. 418-422. 10.1038/clpt.2014.146. Retrieved from https://hdl.handle.net/10161/11171.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Robert Joseph Noveck
Associate Professor of Medicine
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