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    Human endotoxin administration as an experimental model in drug development.

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    Date
    2014-10
    Authors
    Noveck, Robert
    Suffredini, AF
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    Abstract
    Linking human physiology to inflammatory mechanisms discovered in vitro or in animal models is essential to determine their importance. Innate immunity underlies many of these inflammatory responses in health and disease. Bacterial endotoxin is the quintessential trigger of innate immune responses. When administered to humans, endotoxin has been an important means of demonstrating key inflammatory mechanisms in vivo. Furthermore, endotoxin challenges have provided opportunities to test the effects of novel inflammation-modifying agents in humans.
    Type
    Journal article
    Subject
    Anti-Inflammatory Agents
    Drug Discovery
    Endotoxins
    Humans
    Infection
    Inflammation
    Permalink
    https://hdl.handle.net/10161/11171
    Published Version (Please cite this version)
    10.1038/clpt.2014.146
    Publication Info
    Noveck, Robert; & Suffredini, AF (2014). Human endotoxin administration as an experimental model in drug development. Clin Pharmacol Ther, 96(4). pp. 418-422. 10.1038/clpt.2014.146. Retrieved from https://hdl.handle.net/10161/11171.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    Robert Joseph Noveck

    Associate Professor of Medicine
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