ALERT: This system is being upgraded on Tuesday December 12. It will not be available
for use for several hours that day while the upgrade is in progress. Deposits to DukeSpace
will be disabled on Monday December 11, so no new items are to be added to the repository
while the upgrade is in progress. Everything should be back to normal by the end of
day, December 12.
Human endotoxin administration as an experimental model in drug development.
Abstract
Linking human physiology to inflammatory mechanisms discovered in vitro or in animal
models is essential to determine their importance. Innate immunity underlies many
of these inflammatory responses in health and disease. Bacterial endotoxin is the
quintessential trigger of innate immune responses. When administered to humans, endotoxin
has been an important means of demonstrating key inflammatory mechanisms in vivo.
Furthermore, endotoxin challenges have provided opportunities to test the effects
of novel inflammation-modifying agents in humans.
Type
Journal articlePermalink
https://hdl.handle.net/10161/11171Published Version (Please cite this version)
10.1038/clpt.2014.146Publication Info
Suffredini, AF; & Noveck, RJ (2014). Human endotoxin administration as an experimental model in drug development. Clin Pharmacol Ther, 96(4). pp. 418-422. 10.1038/clpt.2014.146. Retrieved from https://hdl.handle.net/10161/11171.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Robert Joseph Noveck
Associate Professor of Medicine

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info