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Barriers to and facilitators of interventions to counter publication bias: thematic analysis of scholarly articles and stakeholder interviews.

dc.contributor.author Kien, Christina
dc.contributor.author Nußbaumer, Barbara
dc.contributor.author Thaler, Kylie J
dc.contributor.author Griebler, Ursula
dc.contributor.author Van Noord, Megan G
dc.contributor.author Wagner, Petra
dc.contributor.author Gartlehner, Gerald
dc.contributor.author UNCOVER Project Consortium
dc.coverage.spatial England
dc.date.accessioned 2015-12-17T18:10:32Z
dc.date.issued 2014-11-13
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/25719959
dc.identifier s12913-014-0551-z
dc.identifier.uri https://hdl.handle.net/10161/11192
dc.description.abstract BACKGROUND: When the nature and direction of research results affect their chances of publication, a distortion of the evidence base - termed publication bias - results. Despite considerable recent efforts to implement measures to reduce the non-publication of trials, publication bias is still a major problem in medical research. The objective of our study was to identify barriers to and facilitators of interventions to prevent or reduce publication bias. METHODS: We systematically reviewed the scholarly literature and extracted data from articles. Further, we performed semi-structured interviews with stakeholders. We performed an inductive thematic analysis to identify barriers to and facilitators of interventions to counter publication bias. RESULTS: The systematic review identified 39 articles. Thirty-four of 89 invited interview partners agreed to be interviewed. We clustered interventions into four categories: prospective trial registration, incentives for reporting in peer-reviewed journals or research reports, public availability of individual patient-level data, and peer-review/editorial processes. Barriers we identified included economic and personal interests, lack of financial resources for a global comprehensive trial registry, and different legal systems. Facilitators identified included: raising awareness of the effects of publication bias, providing incentives to make data publically available, and implementing laws to enforce prospective registration and reporting of clinical trial results. CONCLUSIONS: Publication bias is a complex problem that reflects the complex system in which it occurs. The cooperation amongst stakeholders to increase public awareness of the problem, better tailoring of incentives to publish, and ultimately legislative regulations have the greatest potential for reducing publication bias.
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof BMC Health Serv Res
dc.relation.isversionof 10.1186/s12913-014-0551-z
dc.subject Biomedical Research
dc.subject Humans
dc.subject Peer Review
dc.subject Prospective Studies
dc.subject Publication Bias
dc.subject Publishing
dc.subject Registries
dc.subject Research Report
dc.subject Surveys and Questionnaires
dc.subject United Kingdom
dc.title Barriers to and facilitators of interventions to counter publication bias: thematic analysis of scholarly articles and stakeholder interviews.
dc.type Journal article
duke.contributor.id Van Noord, Megan G|0637406
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/25719959
pubs.begin-page 551
pubs.organisational-group Duke
pubs.organisational-group Staff
pubs.publication-status Published online
pubs.volume 14
dc.identifier.eissn 1472-6963


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