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Global view of the functional molecular organization of the avian cerebrum: mirror images and functional columns.

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Date
2013-11
Authors
Jarvis, Erich D
Yu, Jing
Rivas, Miriam V
Horita, Haruhito
Feenders, Gesa
Whitney, Osceola
Jarvis, Syrus C
Jarvis, Electra R
Kubikova, Lubica
Puck, Ana EP
Siang-Bakshi, Connie
Martin, Suzanne
McElroy, Michael
Hara, Erina
Howard, Jason
Pfenning, Andreas
Mouritsen, Henrik
Chen, Chun-Chun
Wada, Kazuhiro
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Abstract
Based on quantitative cluster analyses of 52 constitutively expressed or behaviorally regulated genes in 23 brain regions, we present a global view of telencephalic organization of birds. The patterns of constitutively expressed genes revealed a partial mirror image organization of three major cell populations that wrap above, around, and below the ventricle and adjacent lamina through the mesopallium. The patterns of behaviorally regulated genes revealed functional columns of activation across boundaries of these cell populations, reminiscent of columns through layers of the mammalian cortex. The avian functionally regulated columns were of two types: those above the ventricle and associated mesopallial lamina, formed by our revised dorsal mesopallium, hyperpallium, and intercalated hyperpallium; and those below the ventricle, formed by our revised ventral mesopallium, nidopallium, and intercalated nidopallium. Based on these findings and known connectivity, we propose that the avian pallium has four major cell populations similar to those in mammalian cortex and some parts of the amygdala: 1) a primary sensory input population (intercalated pallium); 2) a secondary intrapallial population (nidopallium/hyperpallium); 3) a tertiary intrapallial population (mesopallium); and 4) a quaternary output population (the arcopallium). Each population contributes portions to columns that control different sensory or motor systems. We suggest that this organization of cell groups forms by expansion of contiguous developmental cell domains that wrap around the lateral ventricle and its extension through the middle of the mesopallium. We believe that the position of the lateral ventricle and its associated mesopallium lamina has resulted in a conceptual barrier to recognizing related cell groups across its border, thereby confounding our understanding of homologies with mammals.
Type
Journal article
Subject
amygdala
basal ganglia
brain evolution
brain organization
brain pathways
claustrum
cortex
forebrain
immediate early genes
motor behavior
neural activity
neurotransmitter receptors
pallidum
pallium
primary sensory
striatum
Animals
Birds
Cell Count
Cerebrum
Gene Expression
Imaging, Three-Dimensional
Nerve Tissue Proteins
Neuroimaging
Neurons
Species Specificity
Permalink
https://hdl.handle.net/10161/11203
Published Version (Please cite this version)
10.1002/cne.23404
Publication Info
Jarvis, Erich D; Yu, Jing; Rivas, Miriam V; Horita, Haruhito; Feenders, Gesa; Whitney, Osceola; ... Wada, Kazuhiro (2013). Global view of the functional molecular organization of the avian cerebrum: mirror images and functional columns. J Comp Neurol, 521(16). pp. 3614-3665. 10.1002/cne.23404. Retrieved from https://hdl.handle.net/10161/11203.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Jarvis

Erich David Jarvis

Adjunct Professor in the Dept. of Neurobiology
Dr. Jarvis' laboratory studies the neurobiology of vocal communication. Emphasis is placed on the molecular pathways involved in the perception and production of learned vocalizations. They use an integrative approach that combines behavioral, anatomical, electrophysiological and molecular biological techniques. The main animal model used is songbirds, one of the few vertebrate groups that evolved the ability to learn vocalizations. The generality of the discoveries is tested in other vocal
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