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Global view of the functional molecular organization of the avian cerebrum: mirror images and functional columns.

dc.contributor.author Jarvis, Erich D
dc.contributor.author Yu, Jing
dc.contributor.author Rivas, Miriam V
dc.contributor.author Horita, Haruhito
dc.contributor.author Feenders, Gesa
dc.contributor.author Whitney, Osceola
dc.contributor.author Jarvis, Syrus C
dc.contributor.author Jarvis, Electra R
dc.contributor.author Kubikova, Lubica
dc.contributor.author Puck, Ana EP
dc.contributor.author Siang-Bakshi, Connie
dc.contributor.author Martin, Suzanne
dc.contributor.author McElroy, Michael
dc.contributor.author Hara, Erina
dc.contributor.author Howard, Jason
dc.contributor.author Pfenning, Andreas
dc.contributor.author Mouritsen, Henrik
dc.contributor.author Chen, Chun-Chun
dc.contributor.author Wada, Kazuhiro
dc.coverage.spatial United States
dc.date.accessioned 2015-12-18T04:45:51Z
dc.date.accessioned 2015-12-18T04:51:47Z
dc.date.issued 2013-11
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/23818122
dc.identifier.uri https://hdl.handle.net/10161/11203
dc.description.abstract Based on quantitative cluster analyses of 52 constitutively expressed or behaviorally regulated genes in 23 brain regions, we present a global view of telencephalic organization of birds. The patterns of constitutively expressed genes revealed a partial mirror image organization of three major cell populations that wrap above, around, and below the ventricle and adjacent lamina through the mesopallium. The patterns of behaviorally regulated genes revealed functional columns of activation across boundaries of these cell populations, reminiscent of columns through layers of the mammalian cortex. The avian functionally regulated columns were of two types: those above the ventricle and associated mesopallial lamina, formed by our revised dorsal mesopallium, hyperpallium, and intercalated hyperpallium; and those below the ventricle, formed by our revised ventral mesopallium, nidopallium, and intercalated nidopallium. Based on these findings and known connectivity, we propose that the avian pallium has four major cell populations similar to those in mammalian cortex and some parts of the amygdala: 1) a primary sensory input population (intercalated pallium); 2) a secondary intrapallial population (nidopallium/hyperpallium); 3) a tertiary intrapallial population (mesopallium); and 4) a quaternary output population (the arcopallium). Each population contributes portions to columns that control different sensory or motor systems. We suggest that this organization of cell groups forms by expansion of contiguous developmental cell domains that wrap around the lateral ventricle and its extension through the middle of the mesopallium. We believe that the position of the lateral ventricle and its associated mesopallium lamina has resulted in a conceptual barrier to recognizing related cell groups across its border, thereby confounding our understanding of homologies with mammals.
dc.language eng
dc.relation.ispartof J Comp Neurol
dc.relation.isversionof 10.1002/cne.23404
dc.relation.replaces http://hdl.handle.net/10161/11200
dc.relation.replaces 10161/11200
dc.subject amygdala
dc.subject basal ganglia
dc.subject brain evolution
dc.subject brain organization
dc.subject brain pathways
dc.subject claustrum
dc.subject cortex
dc.subject forebrain
dc.subject immediate early genes
dc.subject motor behavior
dc.subject neural activity
dc.subject neurotransmitter receptors
dc.subject pallidum
dc.subject pallium
dc.subject primary sensory
dc.subject striatum
dc.subject Animals
dc.subject Birds
dc.subject Cell Count
dc.subject Cerebrum
dc.subject Gene Expression
dc.subject Imaging, Three-Dimensional
dc.subject Nerve Tissue Proteins
dc.subject Neuroimaging
dc.subject Neurons
dc.subject Species Specificity
dc.title Global view of the functional molecular organization of the avian cerebrum: mirror images and functional columns.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/23818122
pubs.begin-page 3614
pubs.end-page 3665
pubs.issue 16
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 521
dc.identifier.eissn 1096-9861


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