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The genomic consequences of adaptive divergence and reproductive isolation between species of manakins.

dc.contributor.author Braun, Michael J
dc.contributor.author Brumfield, RT
dc.contributor.author Buerkle, CA
dc.contributor.author Gompert, Z
dc.contributor.author Jarvis, Erich David
dc.contributor.author McDonald, DB
dc.contributor.author Parchman, TL
dc.contributor.author Schlinger, BA
dc.contributor.author Uy, JA
dc.contributor.author Zhang, G
dc.coverage.spatial England
dc.date.accessioned 2015-12-18T04:55:22Z
dc.date.issued 2013-06
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/23441849
dc.identifier.uri https://hdl.handle.net/10161/11206
dc.description.abstract The processes of adaptation and speciation are expected to shape genomic variation within and between diverging species. Here we analyze genomic heterogeneity of genetic differentiation and introgression in a hybrid zone between two bird species (Manacus candei and M. vitellinus) using 59 100 SNPs, a whole genome assembly, and Bayesian models. Measures of genetic differentiation (FST) and introgression (genomic cline center [α] and rate [β]) were highly heterogeneous among loci. We identified thousands of loci with elevated parameter estimates, some of which are likely to be associated with variation in fitness in Manacus populations. To analyze the genomic organization of differentiation and introgression, we mapped SNPs onto a draft assembly of the M. vitellinus genome. Estimates of FST, α, and β were autocorrelated at very short physical distances (< 100 bp), but much less so beyond this. In addition, average statistical associations (linkage disequilibrium) between SNPs were generally low and were not higher in admixed populations than in populations of the parental species. Although they did not occur with a constant probability across the genome, loci with elevated FST, α, and β were not strongly co-localized in the genome. Contrary to verbal models that predict clustering of loci involved in adaptation and isolation in discrete genomic regions, these results are consistent with the hypothesis that genetic regions involved in adaptive divergence and reproductive isolation are scattered throughout the genome. We also found that many loci were characterized by both exceptional genetic differentiation and introgression, consistent with the hypothesis that loci involved in isolation are also often characterized by a history of divergent selection. However, the concordance between isolation and differentiation was only partial, indicating a complex architecture and history of loci involved in isolation.
dc.language eng
dc.relation.ispartof Mol Ecol
dc.relation.isversionof 10.1111/mec.12201
dc.subject Manacus
dc.subject genomic cline
dc.subject hybrid zone
dc.subject next-generation sequencing
dc.subject population genomics
dc.subject speciation
dc.subject Adaptation, Biological
dc.subject Animals
dc.subject Bayes Theorem
dc.subject Costa Rica
dc.subject Genetic Loci
dc.subject Genetics, Population
dc.subject Genome
dc.subject Hybridization, Genetic
dc.subject Linkage Disequilibrium
dc.subject Models, Genetic
dc.subject Panama
dc.subject Passeriformes
dc.subject Polymorphism, Single Nucleotide
dc.subject Reproductive Isolation
dc.subject Sequence Analysis, DNA
dc.title The genomic consequences of adaptive divergence and reproductive isolation between species of manakins.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/23441849
pubs.begin-page 3304
pubs.end-page 3317
pubs.issue 12
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 22
dc.identifier.eissn 1365-294X


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