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A relationship between behavior, neurotrophin expression, and new neuron survival.

dc.contributor.author Alvarez-Borda, B
dc.contributor.author Jarvis, Erich David
dc.contributor.author Li, XC
dc.contributor.author Lim, DA
dc.contributor.author Nottebohm, F
dc.coverage.spatial United States
dc.date.accessioned 2015-12-19T13:51:54Z
dc.date.issued 2000-07-18
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/10890902
dc.identifier 140222497
dc.identifier.issn 0027-8424
dc.identifier.uri https://hdl.handle.net/10161/11217
dc.description.abstract The high vocal center (HVC) controls song production in songbirds and sends a projection to the robust nucleus of the archistriatum (RA) of the descending vocal pathway. HVC receives new neurons in adulthood. Most of the new neurons project to RA and replace other neurons of the same kind. We show here that singing enhances mRNA and protein expression of brain-derived neurotrophic factor (BDNF) in the HVC of adult male canaries, Serinus canaria. The increased BDNF expression is proportional to the number of songs produced per unit time. Singing-induced BDNF expression in HVC occurs mainly in the RA-projecting neurons. Neuronal survival was compared among birds that did or did not sing during days 31-38 after BrdUrd injection. Survival of new HVC neurons is greater in the singing birds than in the nonsinging birds. A positive causal link between pathway use, neurotrophin expression, and new neuron survival may be common among systems that recruit new neurons in adulthood.
dc.language eng
dc.relation.ispartof Proc Natl Acad Sci U S A
dc.relation.isversionof 10.1073/pnas.140222497
dc.subject Animals
dc.subject Brain
dc.subject Brain-Derived Neurotrophic Factor
dc.subject Canaries
dc.subject Cell Survival
dc.subject Gene Expression
dc.subject Humans
dc.subject Male
dc.subject Neurons
dc.subject RNA, Messenger
dc.subject Vocalization, Animal
dc.title A relationship between behavior, neurotrophin expression, and new neuron survival.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/10890902
pubs.begin-page 8584
pubs.end-page 8589
pubs.issue 15
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 97


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