Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
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We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins. We also identified previously unknown candidates for secreted neuroactive molecules. The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.
Amino Acid Sequence
Molecular Sequence Data
Nervous System Physiological Phenomena
Receptors, Cell Surface
Trinucleotide Repeat Expansion
Published Version (Please cite this version)10.1101/gr.1135303
Publication InfoGustincich, Stefano; Batalov, Serge; Beisel, Kirk W; Bono, Hidemasa; Carninci, Piero; Fletcher, Colin F; ... GSL Members (2003). Analysis of the mouse transcriptome for genes involved in the function of the nervous system. Genome Res, 13(6B). pp. 1395-1401. 10.1101/gr.1135303. Retrieved from https://hdl.handle.net/10161/11220.
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Adjunct Professor in the Dept. of Neurobiology
Dr. Jarvis' laboratory studies the neurobiology of vocal communication. Emphasis is placed on the molecular pathways involved in the perception and production of learned vocalizations. They use an integrative approach that combines behavioral, anatomical, electrophysiological and molecular biological techniques. The main animal model used is songbirds, one of the few vertebrate groups that evolved the ability to learn vocalizations. The generality of the discoveries is tested in other vocal