Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
Abstract
We analyzed the mouse Representative Transcript and Protein Set for molecules involved
in brain function. We found full-length cDNAs of many known brain genes and discovered
new members of known brain gene families, including Family 3 G-protein coupled receptors,
voltage-gated channels, and connexins. We also identified previously unknown candidates
for secreted neuroactive molecules. The existence of a large number of unique brain
ESTs suggests an additional molecular complexity that remains to be explored.A list
of genes containing CAG stretches in the coding region represents a first step in
the potential identification of candidates for hereditary neurological disorders.
Type
Journal articleSubject
AdenineAmino Acid Sequence
Animals
Brain Chemistry
Calcium
Calcium Channels
Chloride Channels
Cytosine
Databases, Genetic
GTP-Binding Proteins
Gene Library
Genes
Guanine
Humans
Mice
Molecular Sequence Data
Nervous System
Nervous System Physiological Phenomena
Neurodegenerative Diseases
Neurons
Neuropeptides
Phylogeny
Receptors, Cell Surface
Transcription, Genetic
Trinucleotide Repeat Expansion
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https://hdl.handle.net/10161/11220Published Version (Please cite this version)
10.1101/gr.1135303Publication Info
Gustincich, Stefano; Batalov, Serge; Beisel, Kirk W; Bono, Hidemasa; Carninci, Piero;
Fletcher, Colin F; ... GSL Members (2003). Analysis of the mouse transcriptome for genes involved in the function of the nervous
system. Genome Res, 13(6B). pp. 1395-1401. 10.1101/gr.1135303. Retrieved from https://hdl.handle.net/10161/11220.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Erich David Jarvis
Adjunct Professor in the Deptartment of Neurobiology
Dr. Jarvis' laboratory studies the neurobiology of vocal communication. Emphasis is
placed on the molecular pathways involved in the perception and production of learned
vocalizations. They use an integrative approach that combines behavioral, anatomical,
electrophysiological and molecular biological techniques. The main animal model used
is songbirds, one of the few vertebrate groups that evolved the ability to learn vocalizations.
The generality of the discoveries is tested in other vocal lear

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