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FoxP2 expression in avian vocal learners and non-learners.

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Date
2004-03-31
Authors
Haesler, Sebastian
Wada, Kazuhiro
Nshdejan, A
Morrisey, Edward E
Lints, Thierry
Jarvis, Eric D
Scharff, Constance
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Abstract
Most vertebrates communicate acoustically, but few, among them humans, dolphins and whales, bats, and three orders of birds, learn this trait. FOXP2 is the first gene linked to human speech and has been the target of positive selection during recent primate evolution. To test whether the expression pattern of FOXP2 is consistent with a role in learned vocal communication, we cloned zebra finch FoxP2 and its close relative FoxP1 and compared mRNA and protein distribution in developing and adult brains of a variety of avian vocal learners and non-learners, and a crocodile. We found that the protein sequence of zebra finch FoxP2 is 98% identical with mouse and human FOXP2. In the avian and crocodilian forebrain, FoxP2 was expressed predominantly in the striatum, a basal ganglia brain region affected in patients with FOXP2 mutations. Strikingly, in zebra finches, the striatal nucleus Area X, necessary for vocal learning, expressed more FoxP2 than the surrounding tissue at post-hatch days 35 and 50, when vocal learning occurs. In adult canaries, FoxP2 expression in Area X differed seasonally; more FoxP2 expression was associated with times when song becomes unstable. In adult chickadees, strawberry finches, song sparrows, and Bengalese finches, Area X expressed FoxP2 to different degrees. Non-telencephalic regions in both vocal learning and non-learning birds, and in crocodiles, were less variable in expression and comparable with regions that express FOXP2 in human and rodent brains. We conclude that differential expression of FoxP2 in avian vocal learners might be associated with vocal plasticity.
Type
Journal article
Subject
Alligators and Crocodiles
Animals
Birds
Brain
Cloning, Molecular
Cues
Forkhead Transcription Factors
In Situ Hybridization
Learning
Male
Molecular Sequence Data
Molecular Weight
Neuronal Plasticity
Neurons
Protein Isoforms
Repressor Proteins
Species Specificity
Transcription Factors
Vocalization, Animal
Permalink
https://hdl.handle.net/10161/11233
Published Version (Please cite this version)
10.1523/JNEUROSCI.4369-03.2004
Publication Info
Haesler, Sebastian; Wada, Kazuhiro; Nshdejan, A; Morrisey, Edward E; Lints, Thierry; Jarvis, Eric D; & Scharff, Constance (2004). FoxP2 expression in avian vocal learners and non-learners. J Neurosci, 24(13). pp. 3164-3175. 10.1523/JNEUROSCI.4369-03.2004. Retrieved from https://hdl.handle.net/10161/11233.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Jarvis

Erich David Jarvis

Adjunct Professor in the Dept. of Neurobiology
Dr. Jarvis' laboratory studies the neurobiology of vocal communication. Emphasis is placed on the molecular pathways involved in the perception and production of learned vocalizations. They use an integrative approach that combines behavioral, anatomical, electrophysiological and molecular biological techniques. The main animal model used is songbirds, one of the few vertebrate groups that evolved the ability to learn vocalizations. The generality of the discoveries is tested in other vocal
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