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FoxP2 expression in avian vocal learners and non-learners.

dc.contributor.author Haesler, S
dc.contributor.author Jarvis, Erich David
dc.contributor.author Lints, T
dc.contributor.author Morrisey, EE
dc.contributor.author Nshdejan, A
dc.contributor.author Scharff, C
dc.contributor.author Wada, K
dc.coverage.spatial United States
dc.date.accessioned 2015-12-19T14:33:08Z
dc.date.issued 2004-03-31
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/15056696
dc.identifier 24/13/3164
dc.identifier.uri https://hdl.handle.net/10161/11233
dc.description.abstract Most vertebrates communicate acoustically, but few, among them humans, dolphins and whales, bats, and three orders of birds, learn this trait. FOXP2 is the first gene linked to human speech and has been the target of positive selection during recent primate evolution. To test whether the expression pattern of FOXP2 is consistent with a role in learned vocal communication, we cloned zebra finch FoxP2 and its close relative FoxP1 and compared mRNA and protein distribution in developing and adult brains of a variety of avian vocal learners and non-learners, and a crocodile. We found that the protein sequence of zebra finch FoxP2 is 98% identical with mouse and human FOXP2. In the avian and crocodilian forebrain, FoxP2 was expressed predominantly in the striatum, a basal ganglia brain region affected in patients with FOXP2 mutations. Strikingly, in zebra finches, the striatal nucleus Area X, necessary for vocal learning, expressed more FoxP2 than the surrounding tissue at post-hatch days 35 and 50, when vocal learning occurs. In adult canaries, FoxP2 expression in Area X differed seasonally; more FoxP2 expression was associated with times when song becomes unstable. In adult chickadees, strawberry finches, song sparrows, and Bengalese finches, Area X expressed FoxP2 to different degrees. Non-telencephalic regions in both vocal learning and non-learning birds, and in crocodiles, were less variable in expression and comparable with regions that express FOXP2 in human and rodent brains. We conclude that differential expression of FoxP2 in avian vocal learners might be associated with vocal plasticity.
dc.language eng
dc.relation.ispartof J Neurosci
dc.relation.isversionof 10.1523/JNEUROSCI.4369-03.2004
dc.subject Alligators and Crocodiles
dc.subject Animals
dc.subject Birds
dc.subject Brain
dc.subject Cloning, Molecular
dc.subject Cues
dc.subject Forkhead Transcription Factors
dc.subject In Situ Hybridization
dc.subject Learning
dc.subject Male
dc.subject Molecular Sequence Data
dc.subject Molecular Weight
dc.subject Neuronal Plasticity
dc.subject Neurons
dc.subject Protein Isoforms
dc.subject Repressor Proteins
dc.subject Species Specificity
dc.subject Transcription Factors
dc.subject Vocalization, Animal
dc.title FoxP2 expression in avian vocal learners and non-learners.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/15056696
pubs.begin-page 3164
pubs.end-page 3175
pubs.issue 13
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 24
dc.identifier.eissn 1529-2401


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