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Social context-dependent singing-regulated dopamine.

dc.contributor.author Sasaki, Aya
dc.contributor.author Sotnikova, Tatyana D
dc.contributor.author Gainetdinov, Raul R
dc.contributor.author Jarvis, Erich D
dc.coverage.spatial United States
dc.date.accessioned 2015-12-22T04:38:54Z
dc.date.issued 2006-08-30
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/16943558
dc.identifier 26/35/9010
dc.identifier.uri https://hdl.handle.net/10161/11266
dc.description.abstract Like the mammalian striatum, the songbird striatum receives dense dopaminergic input from the midbrain ventral tegmental area-substantia nigra pars compacta complex. The songbird striatum also contains a unique vocal nucleus, Area X, which has been implicated in song learning and social context-dependent song production. Area X shows increased neural firing and activity-dependent gene expression when birds sing, and the level of activation is higher and more variable during undirected singing relative to directed singing to other birds. Here we show in the first report of in vivo microdialysis in awake, behaving songbirds that singing is associated with increased dopamine levels in Area X. Dopamine levels are significantly higher with directed relative to undirected singing. This social context-dependent difference in dopamine levels requires the dopamine transporter, because local in vivo blockade of the transporter caused dopamine levels for undirected singing to increase to levels similar to that for directed singing, eliminating the social context-dependent difference. The increase in dopamine is presumably depolarization and vesicular release dependent, because adding of high K+ increased and removal of Ca2+ increased and decreased extracellular DA levels. Our findings implicate DA and molecules that control DA kinetics in singing behavior and social context-dependent brain function.
dc.language eng
dc.publisher Society for Neuroscience
dc.relation.ispartof J Neurosci
dc.relation.isversionof 10.1523/JNEUROSCI.1335-06.2006
dc.subject Animal Communication
dc.subject Animals
dc.subject Basal Ganglia
dc.subject Dopamine
dc.subject Dopamine Plasma Membrane Transport Proteins
dc.subject Electrophysiology
dc.subject Exocytosis
dc.subject Extracellular Fluid
dc.subject Finches
dc.subject Male
dc.subject Microdialysis
dc.subject Social Isolation
dc.subject Vocalization, Animal
dc.title Social context-dependent singing-regulated dopamine.
dc.type Journal article
duke.contributor.id Jarvis, Erich D|0205264
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/16943558
pubs.begin-page 9010
pubs.end-page 9014
pubs.issue 35
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 26
dc.identifier.eissn 1529-2401


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