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Site-specific retinoic acid production in the brain of adult songbirds.

dc.contributor.author Denisenko-Nehrbass, NI
dc.contributor.author Jarvis, E
dc.contributor.author Scharff, C
dc.contributor.author Nottebohm, F
dc.contributor.author Mello, CV
dc.coverage.spatial United States
dc.date.accessioned 2015-12-22T04:42:49Z
dc.date.issued 2000-08
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/10985355
dc.identifier S0896-6273(00)00043-X
dc.identifier.issn 0896-6273
dc.identifier.uri https://hdl.handle.net/10161/11268
dc.description.abstract The song system of songbirds, a set of brain nuclei necessary for song learning and production, has distinctive morphological and functional properties. Utilizing differential display, we searched for molecular components involved in song system regulation. We identified a cDNA (zRalDH) that encodes a class 1 aldehyde dehydrogenase. zRalDH was highly expressed in various song nuclei and synthesized retinoic acid efficiently. Brain areas expressing zRalDH generated retinoic acid. Within song nucleus HVC, only projection neurons not undergoing adult neurogenesis expressed zRalDH. Blocking zRalDH activity in the HVC of juveniles interfered with normal song development. Our results provide conclusive evidence for localized retinoic acid synthesis in an adult vertebrate brain and indicate that the retinoic acid-generating system plays a significant role in the maturation of a learned behavior.
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartof Neuron
dc.subject Aldehyde Dehydrogenase
dc.subject Aldehyde Oxidoreductases
dc.subject Animals
dc.subject Autoradiography
dc.subject Base Sequence
dc.subject Brain
dc.subject Cells, Cultured
dc.subject Cloning, Molecular
dc.subject Disulfiram
dc.subject Drug Implants
dc.subject Gene Expression
dc.subject Isoenzymes
dc.subject Male
dc.subject Molecular Sequence Data
dc.subject Nerve Tissue Proteins
dc.subject Neurons
dc.subject Organ Specificity
dc.subject Retinal Dehydrogenase
dc.subject Sequence Analysis, DNA
dc.subject Sequence Homology, Amino Acid
dc.subject Songbirds
dc.subject Substrate Specificity
dc.subject Tretinoin
dc.subject Vocalization, Animal
dc.title Site-specific retinoic acid production in the brain of adult songbirds.
dc.type Journal article
duke.contributor.id Jarvis, E|0205264
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/10985355
pubs.begin-page 359
pubs.end-page 370
pubs.issue 2
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 27


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