T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.
Abstract
After immunization, activated splenic T cells proliferate in periarteriolar lymphoid
sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter
nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive
emigration, frequently involving more than a single white pulp region. These migrants
constitute a unique set of T helper cells that express antigen-specific alpha beta
TCR, CD3, and CD4, but little or no Thy-1, a differentiation antigen present on the
great majority of peripheral murine T lymphocytes. The origin of CD4+ Thy-1 follicular
T cells appears to be the Thy+ population in the PALS, as both sets commonly share
identical V(D)J rearrangements.
Type
Journal articleSubject
AnimalsAntigens, Thy-1
Down-Regulation
Female
Germinal Center
Mice
Mice, Inbred C57BL
Models, Biological
Molecular Sequence Data
Phenotype
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes, Helper-Inducer
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https://hdl.handle.net/10161/11488Collections
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Show full item recordScholars@Duke
Garnett H. Kelsoe
James B. Duke Distinguished Professor of Immunology
1. Lymphocyte development and antigen-driven diversification of immunoglobulin and
T cell antigen receptor genes. 2. The germinal center reaction and mechanisms for
clonal selection and self - tolerance. The origins of autoimmunity. 3. Interaction
of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses,

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