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Identifying Barriers and Practical Solutions to Conducting Site-Based Research in North America: Exploring Acute Heart Failure Trials As a Case Study.

dc.contributor.author Ambrosy, AP
dc.contributor.author Greene, SJ
dc.contributor.author Krishnamoorthy, A
dc.contributor.author Mentz, Robert John
dc.contributor.author Severance, HW
dc.coverage.spatial United States
dc.date.accessioned 2016-01-11T20:15:04Z
dc.date.issued 2015-10
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26462098
dc.identifier S1551-7136(15)00055-0
dc.identifier.issn 1551-7136
dc.identifier.uri http://hdl.handle.net/10161/11505
dc.description.abstract Although the prognosis of ambulatory heart failure (HF) has improved dramatically there have been few advances in the management of acute HF (AHF). Despite regional differences in patient characteristics, background therapy, and event rates, AHF clinical trial enrollment has transitioned from North America and Western Europe to Eastern Europe, South America, and Asia-Pacific where regulatory burden and cost of conducting research may be less prohibitive. It is unclear if the results of clinical trials conducted outside of North America are generalizable to US patient populations. This article uses AHF as a paradigm and identifies barriers and practical solutions to successfully conducting site-based research in North America.
dc.language eng
dc.relation.ispartof Heart Fail Clin
dc.relation.isversionof 10.1016/j.hfc.2015.07.002
dc.subject Acute heart failure
dc.subject Clinical trials
dc.subject Site-based research
dc.subject Acute Disease
dc.subject Clinical Trials as Topic
dc.subject Guideline Adherence
dc.subject Heart Failure
dc.subject Humans
dc.subject North America
dc.subject Research
dc.subject Research Design
dc.title Identifying Barriers and Practical Solutions to Conducting Site-Based Research in North America: Exploring Acute Heart Failure Trials As a Case Study.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26462098
pubs.begin-page 581
pubs.end-page 589
pubs.issue 4
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 11


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