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Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer

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Date
2015-01-01
Authors
Jia, Qingzhu
Zhou, Junfeng
Chen, Gang
Shi, Yan
Yu, Haili
Guan, Peng
Lin, Regina
Jiang, Ning
Yu, Peiwu
Li, Qi-Jing
Wan, Ying
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Abstract
© 2015 Taylor & Francis Group, LLC.A characteristic immunopathology of human cancers is the induction of tumor antigen-specific T lymphocyte responses within solid tumor tissues. Current strategies for immune monitoring focus on the quantification of the density and differentiation status of tumor-infiltrating T lymphocytes; however, properties of the TCR repertoire - including antigen specificity, clonality, as well as its prognostic significance β remain elusive. In this study, we enrolled 28 gastric cancer patients and collected tumor tissues, adjacent normal mucosal tissues, and peripheral blood samples to study the landscape and compartmentalization of these patients’ TCR β repertoire by deep sequencing analyses. Our results illustrated antigen-driven expansion within the tumor compartment and the contracted size of shared clonotypes in mucosa and peripheral blood. Most importantly, the diversity of mucosal T lymphocytes could independently predict prognosis, which strongly underscores critical roles of resident mucosal T-cells in executing post-surgery immunosurveillance against tumor relapse.
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Journal article
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https://hdl.handle.net/10161/11568
Published Version (Please cite this version)
10.1080/2162402X.2014.1001230
Publication Info
Jia, Qingzhu; Zhou, Junfeng; Chen, Gang; Shi, Yan; Yu, Haili; Guan, Peng; ... Wan, Ying (2015). Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer. OncoImmunology, 4(4). 10.1080/2162402X.2014.1001230. Retrieved from https://hdl.handle.net/10161/11568.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Li

Qi-Jing Li

Adjunct Associate Professor in the Department of Immunology
Recent clinical success in cancer immunotherapy, including immune checkpoint blockades and chimeric antigen receptor T cells, have settled a long-debated question in the field: whether tumors can be recognized and eliminated by our own immune system, specifically, the T lymphocyte. Meanwhile, current limitations of these advanced treatments pinpoint fundamental knowledge deficits in basic T cell biology, especially in the context of tumor-carrying patients. Aiming to develop new immunotherapi
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