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Clinical Insights Into the Biology and Treatment of Pancreatic Cancer.

dc.contributor.author Mettu, Niharika B
dc.contributor.author Abbruzzese, James L
dc.coverage.spatial United States
dc.date.accessioned 2016-02-01T14:57:30Z
dc.date.issued 2016-01
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26759461
dc.identifier 12/1/17
dc.identifier.uri https://hdl.handle.net/10161/11572
dc.description.abstract Pancreatic cancer is a devastating disease with a universally poor prognosis. In 2015, it is estimated that there will be 48,960 new cases of pancreatic cancer and that 40,560 people will die of the disease. The 5-year survival rate is 7.2% for all patients with pancreatic cancer; however, survival depends greatly on the stage at diagnosis. Unfortunately, 53% of patients already have metastatic disease at diagnosis, which corresponds to a 5-year survival rate of 2.4%. Even for the 9% of patients with localized disease confined to the pancreas, the 5-year survival is still modest at only 27.1%. These grim statistics highlight the need for ways to identify cohorts of individuals at highest risk, methods to screen those at highest risk to identify preinvasive pathologic precursors, and development of effective systemic therapies. Recent clinical and translational progress has emphasized the relationship with diabetes, the role of the stroma, and the interplay of each of these with inflammation in the pathobiology of pancreatic cancer. In this article, we will discuss these relationships and how they might translate into novel management strategies for the treatment of this disease.
dc.language eng
dc.publisher American Society of Clinical Oncology (ASCO)
dc.relation.ispartof J Oncol Pract
dc.relation.isversionof 10.1200/JOP.2015.009092
dc.subject Cell Transformation, Neoplastic
dc.subject Combined Modality Therapy
dc.subject Diabetes Mellitus
dc.subject Disease Management
dc.subject Humans
dc.subject Pancreatic Neoplasms
dc.subject Risk Factors
dc.subject Stromal Cells
dc.title Clinical Insights Into the Biology and Treatment of Pancreatic Cancer.
dc.type Journal article
duke.contributor.id Mettu, Niharika B|0267792
duke.contributor.id Abbruzzese, James L|0634557
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26759461
pubs.begin-page 17
pubs.end-page 23
pubs.issue 1
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 12
dc.identifier.eissn 1935-469X
duke.contributor.orcid Mettu, Niharika B|0000-0002-7821-3298


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