Metabolic profiling in Prader-Willi syndrome and nonsyndromic obesity: Sex differences and the role of growth hormone
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© 2015 John Wiley & Sons Ltd.Objectives To identify metabolic factors controlling appetite and insulin sensitivity in PWS and assess effects of GH treatment. Methods We compared amino acids, fatty acids and acylcarnitines in GH-treated and untreated PWS children and obese and lean controls to identify biomarkers associated with ghrelin, peptide YY and markers of insulin sensitivity (adiponectin and HOMA-IR). Results Compared with obese controls (OC), children with PWS had fasting hyperghrelinaemia, hyperadiponectinaemia, hypoinsulinaemia and increased ghrelin/PYY. Hyperghrelinaemia, hyperadiponectinaemia and hypoinsulinaemia were more striking in PWS females than males, and decreases in BCAA were detected only in PWS females. GH-treated PWS subjects had lower leptin and higher IGF-1 and adiponectin than untreated subjects; fasting ghrelin, PYY and insulin levels were comparable. Ghrelin correlated inversely with BCAA in PWS but not OC. Adiponectin correlated negatively with BMIz and HOMA-IR in PWS; in contrast, adiponectin correlated more strongly with BCAA than BMIz or HOMA-IR in OC. Conclusions BCAA levels were lower in PWS females than OC females and correlated inversely with ghrelin. Low BCAA in PWS females may promote hyperghrelinaemia and hyperphagia, while hyperadiponectinaemia may maintain insulin sensitivity despite excess weight gain. GH treatment may reduce leptin and increase adiponectin, but does not affect fasting ghrelin or PYY.
Published Version (Please cite this version)10.1111/cen.12766
Publication InfoBain, James R; Butler, MG; Freemark, Michael Scott; Haqq, AM; Ilkayeva, Olga; Irizarry, Krystal Andrea; & Muehlbauer, Michael J (2015). Metabolic profiling in Prader-Willi syndrome and nonsyndromic obesity: Sex differences and the role of growth hormone. Clinical Endocrinology, 83(6). pp. 797-805. 10.1111/cen.12766. Retrieved from http://hdl.handle.net/10161/11607.
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Associate Professor in Medicine
Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine
The primary objective of my basic research has been to elucidate the roles of placental and fetal hormones in the regulation of maternal metabolism and fetal growth. My work has focused on the lactogenic hormones produced by the pituitary gland and placenta. In recent studies we have used targeted knockout mice to explore the molecular mechanisms by which prolactin and placental lactogen regulate pancreatic beta cell mass and insulin production during pregnancy and postnatal life. I also
Medical Instructor in the Department of Pediatrics
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