Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.
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The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT and MET). Although there is substantial support for the role of EMT in driving cancer cell invasion and dissemination, much less is known about the importance of MET in the later steps of metastatic colonization. We created novel reporters, which integrate transcriptional and post-transcriptional regulation, to test whether MET is required for metastasis in multiple in vivo cancer models. In a model of carcinosarcoma, metastasis occurred via an MET-dependent pathway; however, in two prostate carcinoma models, metastatic colonization was MET independent. Our results provide evidence for both MET-dependent and MET-independent metastatic pathways.
Published Version (Please cite this version)10.1038/onc.2015.497
Publication InfoArmstrong, AJ; Bepler, T; Buckley, Anne Frances; Epstein, JI; Garcia-Blanco, Mariano Agustin; Hish, AJ; ... Zhao, Y (2016). Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. Oncogene, 35(33). pp. 4302-4311. 10.1038/onc.2015.497. Retrieved from https://hdl.handle.net/10161/11682.
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Assistant Professor of Pathology
My basic research focus is on neurogenic stem cells and their involvement in brain development and brain tumors. I work in mouse models using inducible in vivo genetic systems, live imaging, and tissue culture, in addition to histological and biochemical methods. My clinical research interests include neuromuscular diseases. I collaborate with colleagues at Duke on basic and translational research in this area.
Adjunct Professor in the Molecular Genetics and Microbiology
Human and viral genes are complex genetic units of information that are tightly regulated. The laboratory studies three aspects of this regulation: the interface between synthesis of mammalian messenger RNAs and the processing events required to mature these transcripts, the alternative processing of these messenger RNAs to produce multiple proteins from one gene, and the regulation of gene expression in human pathogenic flaviviruses. In the great majority of human transcripts
James B. Duke Distinguished Professor Emeritus of Mathematics
Granular flow Although I worked in granular flow for 15 years, I largely stopped working in this area around 5 years ago. Part of my fascination with this field derived from the fact that typically constitutive equations derived from engineering approximations lead to ill-posed PDE. However, I came to believe that the lack of well-posed governing equations was the major obstacle to progress in the field, and I believe that finding appropriate constitutive relations is a task b
Assistant Professor in Medicine
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