Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.
Abstract
The cascade that culminates in macrometastases is thought to be mediated by phenotypic
plasticity, including epithelial-mesenchymal and mesenchymal-epithelial transitions
(EMT and MET). Although there is substantial support for the role of EMT in driving
cancer cell invasion and dissemination, much less is known about the importance of
MET in the later steps of metastatic colonization. We created novel reporters, which
integrate transcriptional and post-transcriptional regulation, to test whether MET
is required for metastasis in multiple in vivo cancer models. In a model of carcinosarcoma,
metastasis occurred via an MET-dependent pathway; however, in two prostate carcinoma
models, metastatic colonization was MET independent. Our results provide evidence
for both MET-dependent and MET-independent metastatic pathways.
Type
Journal articlePermalink
https://hdl.handle.net/10161/11682Published Version (Please cite this version)
10.1038/onc.2015.497Publication Info
(2016). Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.
Oncogene, 35(33). pp. 4302-4311. 10.1038/onc.2015.497. Retrieved from https://hdl.handle.net/10161/11682.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Andrew John Armstrong
Professor of Medicine
I am a clinical and translational investigator focused on precision therapies and
biomarkers in advanced prostate and other GU cancers. I oversee a large research
team of clinical and lab based investigators focused on improving patient outcomes,
preventing metastatic disease, and understanding the biology of aggressive prostate
cancer. Some key themes:1. Predictors of sensitivity and clinical efficacy of therapies
in advanced prostate cancer 2. Novel designs of clinical
Anne Frances Buckley
Associate Professor of Pathology
My basic research focus is on neurogenic stem cells and their involvement in brain
development and brain tumors. I work in mouse models using inducible in vivo genetic
systems, live imaging, and tissue culture, in addition to histological and biochemical
methods. My clinical research interests include neuromuscular diseases. I collaborate
with colleagues at Duke on basic and translational research in this area.
Mariano Agustin Garcia-Blanco
Adjunct Professor in the Molecular Genetics and Microbiology
Human and viral genes are complex genetic units of information that are tightly regulated.
The laboratory studies three aspects of this regulation: the interface between synthesis
of mammalian messenger RNAs and the processing events required to mature these transcripts,
the alternative processing of these messenger RNAs to produce multiple proteins from
one gene, and the regulation of gene expression in human pathogenic flaviviruses.
In the great majority of human transcripts
Jason Andrew Somarelli
Assistant Professor in Medicine
David Marc Virshup
Professor of Pediatrics
Wnt Signaling and Cancer Biology; Circadian Rhythms; Pediatric Hematology/Oncology
Alphabetical list of authors with Scholars@Duke profiles.
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info