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Frontal eye field neurons with spatial representations predicted by their subcortical input.

dc.contributor.author Crapse, Trinity
dc.contributor.author Sommer, Marc A
dc.coverage.spatial United States
dc.date.accessioned 2016-03-25T02:33:54Z
dc.date.issued 2009-04-22
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/19386927
dc.identifier 29/16/5308
dc.identifier.uri https://hdl.handle.net/10161/11730
dc.description.abstract The frontal eye field (FEF) is a cortical structure involved in cognitive aspects of eye movement control. Neurons in the FEF, as in most of cerebral cortex, primarily represent contralateral space. They fire for visual stimuli in the contralateral field and for saccadic eye movements made to those stimuli. Yet many FEF neurons engage in sophisticated functions that require flexible spatial representations such as shifting receptive fields and vector subtraction. Such functions require knowledge about all of space, including the ipsilateral hemifield. How does the FEF gain access to ipsilateral information? Here, we provide evidence that one source of ipsilateral information may be the opposite superior colliculus (SC) in the midbrain. We physiologically identified neurons in the FEF that receive input from the opposite SC, same-side SC, or both. We found a striking structure-function relationship: the laterality of the response field of an FEF neuron was predicted by the laterality of its SC inputs. FEF neurons with input from the opposite SC had ipsilateral fields, whereas neurons with input from the same-side SC had contralateral fields. FEF neurons with input from both SCs had lateralized fields that could point in any direction. The results suggest that signals from the two SCs provide each FEF with information about all of visual space, a prerequisite for higher level sensorimotor computations.
dc.language eng
dc.relation.ispartof J Neurosci
dc.relation.isversionof 10.1523/JNEUROSCI.4906-08.2009
dc.subject Animals
dc.subject Cerebral Cortex
dc.subject Macaca mulatta
dc.subject Neurons
dc.subject Photic Stimulation
dc.subject Predictive Value of Tests
dc.subject Psychomotor Performance
dc.subject Superior Colliculi
dc.subject Visual Fields
dc.subject Visual Pathways
dc.title Frontal eye field neurons with spatial representations predicted by their subcortical input.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/19386927
pubs.begin-page 5308
pubs.end-page 5318
pubs.issue 16
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 29
dc.identifier.eissn 1529-2401


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