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What the brain stem tells the frontal cortex. I. Oculomotor signals sent from superior colliculus to frontal eye field via mediodorsal thalamus.

dc.contributor.author Sommer, Marc A
dc.contributor.author Wurtz, RH
dc.coverage.spatial United States
dc.date.accessioned 2016-03-25T03:12:34Z
dc.date.issued 2004-03
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/14573558
dc.identifier 00738.2003
dc.identifier.issn 0022-3077
dc.identifier.uri http://hdl.handle.net/10161/11745
dc.description.abstract Neuronal processing in cerebral cortex and signal transmission from cortex to brain stem have been studied extensively, but little is known about the numerous feedback pathways that ascend from brain stem to cortex. In this study, we characterized the signals conveyed through an ascending pathway coursing from the superior colliculus (SC) to the frontal eye field (FEF) via mediodorsal thalamus (MD). Using antidromic and orthodromic stimulation, we identified SC source neurons, MD relay neurons, and FEF recipient neurons of the pathway in Macaca mulatta. The monkeys performed oculomotor tasks, including delayed-saccade tasks, that permitted analysis of signals such as visual activity, delay activity, and presaccadic activity. We found that the SC sends all of these signals into the pathway with no output selectivity, i.e., the signals leaving the SC resembled those found generally within the SC. Visual activity arrived in FEF too late to contribute to short-latency visual responses there, and delay activity was largely filtered out in MD. Presaccadic activity, however, seemed critical because it traveled essentially unchanged from SC to FEF. Signal transmission in the pathway was fast ( approximately 2 ms from SC to FEF) and topographically organized (SC neurons drove MD and FEF neurons having similarly eccentric visual and movement fields). Our analysis of identified neurons in one pathway from brain stem to frontal cortex thus demonstrates that multiple signals are sent from SC to FEF with presaccadic activity being prominent. We hypothesize that a major signal conveyed by the pathway is corollary discharge information about the vector of impending saccades.
dc.language eng
dc.relation.ispartof J Neurophysiol
dc.relation.isversionof 10.1152/jn.00738.2003
dc.subject Animals
dc.subject Blinking
dc.subject Brain Stem
dc.subject Electric Stimulation
dc.subject Electrodes
dc.subject Electrophysiology
dc.subject Feedback
dc.subject Fixation, Ocular
dc.subject Frontal Lobe
dc.subject Macaca mulatta
dc.subject Mediodorsal Thalamic Nucleus
dc.subject Neurons
dc.subject Photic Stimulation
dc.subject Psychomotor Performance
dc.subject Saccades
dc.subject Superior Colliculi
dc.subject Visual Fields
dc.subject Visual Pathways
dc.title What the brain stem tells the frontal cortex. I. Oculomotor signals sent from superior colliculus to frontal eye field via mediodorsal thalamus.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/14573558
pubs.begin-page 1381
pubs.end-page 1402
pubs.issue 3
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 91


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