Show simple item record

Identifying corollary discharges for movement in the primate brain.

dc.contributor.author Sommer, Marc A
dc.contributor.author Wurtz, RH
dc.coverage.spatial Netherlands
dc.date.accessioned 2016-03-25T03:13:15Z
dc.date.issued 2004
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/14650839
dc.identifier S0079-6123(03)14403-2
dc.identifier.issn 0079-6123
dc.identifier.uri https://hdl.handle.net/10161/11746
dc.description.abstract The brain keeps track of the movements it makes so as to process sensory input accurately and coordinate complex movements gracefully. In this chapter we review the brain's strategies for keeping track of fast, saccadic eye movements. One way it does this is by monitoring copies of saccadic motor commands, or corollary discharges. It has been difficult to identify corollary discharge signals in the primate brain, although in some studies the influence of corollary discharge, for example on visual processing, has been found. We propose four criteria for identifying corollary discharge signals in primate brain based on our experiences studying a pathway from superior colliculus, in the brainstem, through mediodorsal thalamus to frontal eye field, in the prefrontal cortex. First, the signals must originate from a brain structure involved in generating movements. Second, they must begin just prior to movements and represent spatial attributes of the movements. Third, eliminating the signals should not impair movements in simple tasks not requiring corollary discharge. Fourth, eliminating the signals should, however, disrupt movements in tasks that require corollary discharge, such as a double-step task in which the monkey must keep track of one saccade in order to correctly generate another. Applying these criteria to the pathway from superior colliculus to frontal eye field, we concluded that it does indeed convey corollary discharge signals. The extent to which cerebral cortex actually uses these signals, particularly in the realm of sensory perception, remains unknown pending further studies. Moreover, many other ascending pathways from brainstem to cortex remain to be explored in behaving monkeys, and some of these, too, may carry corollary discharge signals.
dc.language eng
dc.relation.ispartof Prog Brain Res
dc.relation.isversionof 10.1016/S0079-6123(03)14403-2
dc.subject Animals
dc.subject Brain
dc.subject Electrophysiology
dc.subject Humans
dc.subject Motor Activity
dc.subject Primates
dc.subject Visual Perception
dc.title Identifying corollary discharges for movement in the primate brain.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/14650839
pubs.begin-page 47
pubs.end-page 60
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 144


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record