Show simple item record

Multielectrode evidence for spreading activity across the superior colliculus movement map.

dc.contributor.author Port, NL
dc.contributor.author Sommer, Marc A
dc.contributor.author Wurtz, RH
dc.coverage.spatial United States
dc.date.accessioned 2016-03-25T03:20:00Z
dc.date.issued 2000-07
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/10899209
dc.identifier.issn 0022-3077
dc.identifier.uri http://hdl.handle.net/10161/11751
dc.description.abstract The monkey superior colliculus (SC) has maps for both visual input and movement output in the superficial and intermediate layers, respectively, and activity on these maps is generally related to visual stimuli only in one part of the visual field and/or to a restricted range of saccadic eye movements to those stimuli. For some neurons within these maps, however, activity has been reported to spread from the caudal SC to the rostral SC during the course of a saccade. This spread of activity was inferred from averages of recordings at different sites on the SC movement map during saccades of different amplitudes and even in different monkeys. In the present experiments, SC activity was recorded simultaneously in pairs of neurons to observe the spread of activity during individual saccades. Two electrodes were positioned along the rostral-caudal axis of the SC with one being more caudal than the other, and 60 neuron pairs whose movement fields were large enough to see a spread of activity were studied. During individual saccades, the relative time of discharge of the two neurons was compared using 1) the time difference between peak discharge of the two neurons, 2) the difference between the "median activation time" of the two neurons, and 3) the shift required to align the two discharge patterns using cross-correlation. All three analysis methods gave comparable results. Many pairs of neurons were activated in sequence during saccade generation, and the order of activation was most frequently caudal to rostral. Such a sequence of activation was not observed in every neuron pair, but over the sample of neuron pairs studied, the spread was statistically significant. When we compared the time of neuronal activity to the time of saccade onset, we found that the caudal neuronal activity was more likely to be before the saccade, whereas the rostral neuronal activity was more likely to be during the saccade. These results demonstrate that when individual pairs of neurons are examined during single saccades there is evidence of a caudal to rostral spread of activity within the monkey SC, and they confirm the previous inferences of a spread of activity drawn from observations on averaged neuronal activity during multiple saccades. The functional contribution of this spread of activity remains to be determined.
dc.language eng
dc.relation.ispartof J Neurophysiol
dc.subject Animals
dc.subject Brain Mapping
dc.subject Conditioning (Psychology)
dc.subject Electrodes, Implanted
dc.subject Electrophysiology
dc.subject Macaca mulatta
dc.subject Neurons
dc.subject Saccades
dc.subject Superior Colliculi
dc.title Multielectrode evidence for spreading activity across the superior colliculus movement map.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/10899209
pubs.begin-page 344
pubs.end-page 357
pubs.issue 1
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 84


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record