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Electrically evoked saccades from the dorsomedial frontal cortex and frontal eye fields: a parametric evaluation reveals differences between areas.

dc.contributor.author Sommer, Marc A
dc.contributor.author Tehovnik, EJ
dc.coverage.spatial Germany
dc.date.accessioned 2016-03-25T03:27:24Z
dc.date.issued 1997-12
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/9438704
dc.identifier.issn 0014-4819
dc.identifier.uri https://hdl.handle.net/10161/11760
dc.description.abstract Using electrical stimulation to evoke saccades from the dorsomedial frontal cortex (DMFC) and frontal eye fields (FEF) of rhesus monkeys, parametric tests were conducted to compare the excitability properties of these regions. Pulse frequency and pulse current, pulse frequency and train duration, and pulse current and pulse duration were varied to determine threshold functions for a 50% probability of evoking a saccade. Also a wide range of frequencies were tested to evoke saccades, while holding all other parameters constant. For frequencies beyond 150 Hz, the probability of evoking saccades decreased for the DMFC, whereas for the FEF this probability remained at 100%. To evoke saccades readily from the DMFC, train durations of greater than 200 ms were needed; for the FEF, durations of less than 100 ms were sufficient. Even though the chronaxies of neurons residing in the DMFC and FEF were similar (ranging from 0.1 to 0.24 ms) significantly higher currents were required to evoke saccades from the DMFC than FEF. Thus the stimulation parameters that are optimal for evoking saccades from the DMFC differ from those that are optimal for evoking saccades from the FEF. Although the excitability of neurons in the DMFC and FEF are similar (due to similar chronaxies), we suggest that the density of saccade-relevant neurons is higher in the FEF than in the DMFC.
dc.language eng
dc.relation.ispartof Exp Brain Res
dc.subject Animals
dc.subject Chronaxy
dc.subject Electric Stimulation
dc.subject Fixation, Ocular
dc.subject Frontal Lobe
dc.subject Macaca mulatta
dc.subject Neurons
dc.subject Saccades
dc.subject Visual Fields
dc.title Electrically evoked saccades from the dorsomedial frontal cortex and frontal eye fields: a parametric evaluation reveals differences between areas.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/9438704
pubs.begin-page 369
pubs.end-page 378
pubs.issue 3
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 117


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