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Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags.

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Date
2016-03
Authors
Theis, T
Ortiz, GX
Logan, AWJ
Claytor, KE
Feng, Y
Huhn, WP
Blum, V
Malcolmson, SJ
Chekmenev, EY
Wang, Q
Warren, WS
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(11 total)
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Abstract
Conventional magnetic resonance (MR) faces serious sensitivity limitations which can be overcome by hyperpolarization methods, but the most common method (dynamic nuclear polarization) is complex and expensive, and applications are limited by short spin lifetimes (typically seconds) of biologically relevant molecules. We use a recently developed method, SABRE-SHEATH, to directly hyperpolarize (15)N2 magnetization and long-lived (15)N2 singlet spin order, with signal decay time constants of 5.8 and 23 minutes, respectively. We find >10,000-fold enhancements generating detectable nuclear MR signals that last for over an hour. (15)N2-diazirines represent a class of particularly promising and versatile molecular tags, and can be incorporated into a wide range of biomolecules without significantly altering molecular function.
Type
Journal article
Subject
Magnetic resonance
hyperpolarization
nuclear spin states
Permalink
https://hdl.handle.net/10161/11770
Published Version (Please cite this version)
10.1126/sciadv.1501438
Publication Info
Theis, T; Ortiz, GX; Logan, AWJ; Claytor, KE; Feng, Y; Huhn, WP; ... Warren, WS (2016). Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags. Sci Adv, 2(3). pp. e1501438. 10.1126/sciadv.1501438. Retrieved from https://hdl.handle.net/10161/11770.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Blum

Volker Blum

Associate Professor in the Department of Mechanical Engineering and Materials Science
Volker Blum heads the "Ab initio materials simulations" group at Duke University. Dr. Blum's research focuses on "first-principles" computational materials science: using the fundamental laws of quantum mechanics to predict the properties of real materials from the atomic scale on upwards. Specific focus areas are interface and nanoscale systems with electronic and energy applications, as well as work on molecular structure and spectroscopy. R
Huhn

William Huhn

Postdoctoral Associate
Computational materials scientist specializing in high performance resources and next-generation hardware architectures.
Malcolmson

Steven Malcolmson

Associate Professor of Chemistry
The discovery of catalysts is of great importance to the practice of modern synthetic chemistry, both to improve upon the existing catalog of chemical transformations and to generate new modes of reactivity.  Research in the Malcolmson lab focuses on the discovery of novel methods for the efficient and selective synthesis of small molecule scaffolds through the design and development of new catalysts.  In these transformations, we seek to
Theis

Thomas Theis

Assistant Research Professor of Chemistry
Theis' research is at the intersection of Spin Physics and Hyperpolarization Chemistry. It has applications in the study of biochemical dynamics and molecular imaging. The Theis lab drives innovation of magnetic resonance tools and techniques to break the sensitivity limits of NMR  and MRI. The innovations enable i) biochemical structure elucidation with unprecedented limits of detection, and ii) molecular imaging to spy on mole
Wang

Qiu Wang

Robert R. & Katherine B. Penn Associate Professor
Research in the Wang group aims to answer fundamental questions that lie at the interface of chemistry and biology. In particular, we are interested in developing small-molecule based probes and methods to understand the cause of disease with an emphasis on identifying potential therapeutic agents towards cancer and neurodegenerative disorders. Bioactive molecules as probes in human biology and disease. Starting from naturally occurring molecules that possess u
Warren

Warren S. Warren

James B. Duke Distinguished Professor of Chemistry
Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collabo
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