Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature.
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UNLABELLED: Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00065806.
SubjectCell- and Tissue-Based Therapy
Lupus Erythematosus, Systemic
Severity of Illness Index
Vitamin D Deficiency
Published Version (Please cite this version)10.1186/s12969-015-0008-x
Publication InfoGurion, R; Tangpricha, V; Yow, E; Schanberg, LE; McComsey, GA; Robinson, AB; & Atherosclerosis Prevention in Pediatric Lupus Erythematosus Investigators (2015). Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature. Pediatr Rheumatol Online J, 13. pp. 13. 10.1186/s12969-015-0008-x. Retrieved from http://hdl.handle.net/10161/11781.
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