The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach.
Abstract
Here we examine the effects of both self-reported and independent observer-reported
environmental risk indices, the serotonin transporter gene promoter (5HTTLPR) polymorphism,
and their interaction on self-esteem. This trait was assessed during early and mid
adolescence (mean age=14 and 16.5, respectively) and young adulthood (mean age=21.8)
in a prospective cohort of 1214 unrelated participants in the Longitudinal Study of
Adolescent Health (Add Health). Using structural equation modeling we identified a
gene-environment (G×E) interaction using observer-report but not self-report measures
of environmental stress exposure during adolescence: 5HTTLPR genotype and observer-reports
of home and neighborhood quality (HNQ) during adolescence interacted to predict self-esteem
levels in young adulthood (p<.004). Carriers of the s allele who lived in poor HNQ
conditions during adolescence reported lower self-esteem in young adulthood than those
with a good HNQ during adolescence. In contrast, among individuals with the l/l genotype,
adolescent HNQ did not predict adulthood self-esteem. Genes may moderate the effect
of adolescent environmental conditions on adulthood self-esteem.
Type
Journal articleSubject
AdolescentAlleles
Child
Female
Gene-Environment Interaction
Genotype
Humans
Longitudinal Studies
Male
Polymorphism, Genetic
Psychology, Adolescent
Self Concept
Serotonin Plasma Membrane Transport Proteins
Social Environment
Young Adult
Permalink
https://hdl.handle.net/10161/11803Published Version (Please cite this version)
10.1016/j.biopsycho.2012.05.004Publication Info
(2012). The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent
environmental conditions on self-esteem in young adulthood: a structural equation
modeling approach. Biol Psychol, 91(1). pp. 111-119. 10.1016/j.biopsycho.2012.05.004. Retrieved from https://hdl.handle.net/10161/11803.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Allison Elizabeth Ashley-Koch
Professor in Medicine
One of my major research foci is in the genetic basis of psychiatric and neurological
disorders. I am currently involved in studies to dissect the genetic etiology of
attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations,
essential tremor, and neural tube defects. Additional research foci include genetic
modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly
among African American women.
Rick Hoyle
Professor of Psychology and Neuroscience
Research in my lab concerns the means by which adolescents and emerging adults manage
pursuit of their goals through self-regulation. We take a broad view of self-regulation,
accounting for the separate and interactive influences of personality, environment
(e.g., home, school, neighborhood), cognition and emotion, and social influences on
the many facets of goal management. Although we occasionally study these influences
in controlled laboratory experiments, our preference is to study the pu
Laura Smart Richman
Associate Professor in Population Health Sciences
Dr. Richman's research broadly focuses on understanding factors that contribute to
health disparities for disadvantaged groups. Some research areas include the role
of social status, gentrification, and social network characteristics on health behaviors
and outcomes. Click here for .pdf links to my publicationsAreas of expertise: Health
Charmaine DM Royal
Robert O. Keohane Professor
Charmaine Royal is the Robert O. Keohane Professor of African & African American Studies,
Biology, Global Health, and Family Medicine & Community Health at Duke University.
She directs the Center on Genomics, Race, Identity, Difference and the Center for
Truth, Racial Healing & Transformation.
Dr. Royal’s research, scholarship, and teaching focus on ethical, social, scientific,
and clinical implications of human genetics and genomics, particularly issues at the
inter
Ilene C. Siegler
Professor in Psychiatry and Behavioral Sciences
My research efforts are in the area of developmental health psychology and organized
around understanding the role of personality in health and disease in middle and later
life. My primary research activity is as Principal Investigator of the UNC Alumni
Heart Study (UNCAHS) a prospective epidemiologic study of 5000 middle aged men and
women and 1200 of their spouses that evaluates the role of personality on coronary
heart disease and coronary heart disease risk, cancer, and normal a
Keith E. Whitfield
Professor of Psychology and Neuroscience
Dr. Whitfield's research on individual differences in minority aging employs a two
prong approach that includes studying individual people as well as members of twin
pairs. Dr. Whitfield’s research examines the individual variation in health and individual
differences in cognition due to health conditions. Dr. Whitfield has worked with researchers
from Sweden, Russia, and the United States to examine how social, psychological, and
cultural factors of cognition and healthy aging. He has complet
Redford B. Williams Jr.
Professor Emeritus of Psychiatry and Behavioral Sciences
My research aims to identify psychosocial factors that are involved in the pathogenesis
and course of major medical disorders, to characterize the biobehavioral mechanisms
whereby such factors influence disease, and to develop both behavioral and pharmacologic
means of preventing or ameliorating the adverse impact of psychosocial factors on
health and disease. Specific projects that are currently active include: 1) The influence
of hostile personality, social isolation, depression and other psyc
Alphabetical list of authors with Scholars@Duke profiles.
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info