Show simple item record

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

dc.contributor.author Lv, Y-B
dc.contributor.author Yin, ZX
dc.contributor.author Chei, C-L
dc.contributor.author Brasher, MS
dc.contributor.author Zhang, J
dc.contributor.author Kraus, VB
dc.contributor.author Qian, F
dc.contributor.author Shi, X-M
dc.contributor.author Matchar, DB
dc.contributor.author Zeng, Y
dc.date.accessioned 2016-05-01T23:31:17Z
dc.date.issued 2016-03-01
dc.identifier.issn 1279-7707
dc.identifier.uri https://hdl.handle.net/10161/11952
dc.description.abstract © 2016, Serdi and Springer-Verlag France.Objectives: The association between cognitive function and cholesterol levels is poorly understood and inconsistent results exist among the elderly. The purpose of this study is to investigate the association of cholesterol level with cognitive performance among Chinese elderly. Design: A cross-sectional study was implemented in 2012 and data were analyzed using generalized additive models, linear regression models and logistic regression models. Setting: Community-based setting in eight longevity areas in China. Subjects: A total of 2000 elderly aged 65 years and over (mean 85.8±12.0 years) participated in this study. Measurements: Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) concentration were determined and cognitive impairment was defined as Mini-Mental State Examination (MMSE) score≤23. Results: There was a significant positive linear association between TC, TG, LDL-C, HDL-C and MMSE score in linear regression models. Each 1 mmol/L increase in TC, TG, LDL-C and HDL-C corresponded to a decreased risk of cognitive impairment in logistic regression models. Compared with the lowest tertile, the highest tertile of TC, LDL-C and HDL-C had a lower risk of cognitive impairment. The adjusted odds ratios and 95% CI were 0.73(0.62–0.84) for TC, 0.81(0.70–0.94) for LDL-C and 0.81(0.70–0.94) for HDL-C. There was no gender difference in the protective effects of high TC and LDL-C levels on cognitive impairment. However, for high HDL-C levels the effect was only observed in women. High TC, LDL-C and HDL-C levels were associated with lower risk of cognitive impairment in the oldest old (aged 80 and older), but not in the younger elderly (aged 65 to 79 years). Conclusions: These findings suggest that cholesterol levels within the high normal range are associated with better cognitive performance in Chinese elderly, specifically in the oldest old. With further validation, low cholesterol may serve a clinical indicator of risk for cognitive impairment in the elderly.
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof Journal of Nutrition, Health and Aging
dc.relation.isversionof 10.1007/s12603-016-0701-6
dc.title Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly
dc.type Journal article
duke.contributor.id Kraus, VB|0078823
duke.contributor.id Matchar, DB|0063297
pubs.begin-page 280
pubs.end-page 287
pubs.issue 3
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Global Health Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, General Internal Medicine
pubs.organisational-group Medicine, Rheumatology and Immunology
pubs.organisational-group Orthopaedics
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 20
dc.identifier.eissn 1760-4788
duke.contributor.orcid Kraus, VB|0000-0001-8173-8258
duke.contributor.orcid Matchar, DB|0000-0003-3020-2108


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record