A LabVIEW Platform for Preclinical Imaging Using Digital Subtraction Angiography and Micro-CT.
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CT and digital subtraction angiography (DSA) are ubiquitous in the clinic. Their preclinical equivalents are valuable imaging methods for studying disease models and treatment. We have developed a dual source/detector X-ray imaging system that we have used for both micro-CT and DSA studies in rodents. The control of such a complex imaging system requires substantial software development for which we use the graphical language LabVIEW (National Instruments, Austin, TX, USA). This paper focuses on a LabVIEW platform that we have developed to enable anatomical and functional imaging with micro-CT and DSA. Our LabVIEW applications integrate and control all the elements of our system including a dual source/detector X-ray system, a mechanical ventilator, a physiological monitor, and a power microinjector for the vascular delivery of X-ray contrast agents. Various applications allow cardiac- and respiratory-gated acquisitions for both DSA and micro-CT studies. Our results illustrate the application of DSA for cardiopulmonary studies and vascular imaging of the liver and coronary arteries. We also show how DSA can be used for functional imaging of the kidney. Finally, the power of 4D micro-CT imaging using both prospective and retrospective gating is shown for cardiac imaging.
Published Version (Please cite this version)10.1155/2013/581617
Publication InfoBadea, CT; Hedlund, Laurence W; & Johnson, G Allan (2013). A LabVIEW Platform for Preclinical Imaging Using Digital Subtraction Angiography and Micro-CT. J Med Eng, 2013. pp. 581617. 10.1155/2013/581617. Retrieved from http://hdl.handle.net/10161/11992.
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Professor Emeritus of Radiology
Currently, major effort is devoted to developing and utilizing magnetic resonance (MR) microscopy for in vivo histologic studies of major organs systems in small animals such as rats and guinea pigs. This work takes two directions: 1. development of monitoring and physiologic and support systems and 2. examination of magnetic resonance correlates of the microscopic changes that occur in the lungs, liver, kidneys, brain and blood vessels. MR imaging at microscopic resolution in live s