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Validation of Coded Aperture Coherent Scatter Spectral Imaging for Differentiation of Normal and Neoplastic Breast Tissues via Surgical Pathology

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Date
2016
Author
Morris, Robert Elliott
Advisor
Kapadia, Anuj J
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Abstract

This study intends to validate the sensitivity and specificity of coded aperture coherent scatter spectral imaging (CACSSI) by comparison to clinical histological preparation and pathologic analysis methods currently used for the differentiation of normal and neoplastic breast tissues. A composite overlay of the CACSSI rendered image and pathologist interpreted, stained sections validate the ability of coherent scatter imaging to differentiate cancerous tissues from normal, healthy breast structures ex-vivo. Via comparison to the pathologist annotated slides, the CACSSI system may be further optimized to maximized sensitivity and specificity for differentiation of breast carcinomas.

Type
Master's thesis
Department
Medical Physics
Subject
Medical imaging
breast imaging
coded aperture
spectral imaging
Permalink
https://hdl.handle.net/10161/12358
Citation
Morris, Robert Elliott (2016). Validation of Coded Aperture Coherent Scatter Spectral Imaging for Differentiation of Normal and Neoplastic Breast Tissues via Surgical Pathology. Master's thesis, Duke University. Retrieved from https://hdl.handle.net/10161/12358.
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