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A systematic review of evidence for silver nanoparticle-induced mitochondrial toxicity

dc.contributor.author Maurer, LL
dc.contributor.author Meyer, Joel
dc.date.accessioned 2016-07-01T15:17:25Z
dc.date.issued 2016-04-01
dc.identifier.issn 2051-8153
dc.identifier.uri https://hdl.handle.net/10161/12420
dc.description.abstract © The Royal Society of Chemistry 2016.Silver nanoparticles (AgNPs) are extensively used for their antibacterial properties in a diverse set of applications, ranging from the treatment of municipal wastewater to infection control in hospitals. However, the properties of AgNPs that render them conducive to bactericidal use in commerce may influence their potential toxicity to non-bacterial organisms. Based on the physiological and phylogenetic similarities between bacteria and mitochondria within eukaryotic cells, mitochondria are a likely intracellular target of AgNP toxicity. Mitochondria-specific outcomes of AgNP exposures have been identified in multiple cell types, including (but not limited to) loss of membrane potential, inhibition of enzymes involved in oxidative phosphorylation, and changes in calcium sequestration. However, the biological significance of mitochondrial toxicity due to AgNP exposure is currently incompletely understood. This review examines the existing evidence of mitochondrial toxicity induced by AgNP exposure, with discussions of the role of the physicochemical properties of the nanoparticles themselves in mitochondrial toxicity. The impacts of potentially differential cell- and tissue-specific significance of AgNP-induced mitochondrial dysfunction are also discussed.
dc.relation.ispartof Environmental Science: Nano
dc.relation.isversionof 10.1039/c5en00187k
dc.title A systematic review of evidence for silver nanoparticle-induced mitochondrial toxicity
dc.type Journal article
pubs.begin-page 311
pubs.end-page 322
pubs.issue 2
pubs.organisational-group Civil and Environmental Engineering
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Environmental Sciences and Policy
pubs.organisational-group Global Health Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Nicholas School of the Environment
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 3
dc.identifier.eissn 2051-8161


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