Why Serological Responses during Cystitis are Limited.
Abstract
The high frequency of urinary tract infections (UTIs), some of which appear to be
endogenous relapses rather than reinfections by new isolates, point to defects in
the host's memory immune response. It has been known for many decades that, whereas
kidney infections evoked an antibody response to the infecting bacteria, infections
limited to the bladder failed to do so. We have identified the existence of a broadly
immunosuppressive transcriptional program associated with the bladder, but not the
kidneys, during infection of the urinary tract that is dependent on bladder mast cells.
This involves the localized secretion of IL-10 and results in the suppression of humoral
immune responses in the bladder. Mast cell-mediated immune suppression could suggest
a role for these cells in critically balancing the needs to clear infections with
the imperative to prevent harmful immune reactions in the host.
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Journal articlePermalink
https://hdl.handle.net/10161/12469Published Version (Please cite this version)
10.3390/pathogens5010019Publication Info
Choi, Hae Woong; & Abraham, Soman N (2016). Why Serological Responses during Cystitis are Limited. Pathogens, 5(1). 10.3390/pathogens5010019. Retrieved from https://hdl.handle.net/10161/12469.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Soman Ninan Abraham
Grace Kerby Distinguished Professor of Pathology
The Abraham laboratory is interested in developing innovative approaches for curbing
microbial infections through the study of the molecular interactions occurring between
pathogenic bacteria and prominent immune and epithelial cells. We believe that there
is a significant amount of crosstalk occurring between bacteria and host cells during
infection and that the outcome of this interaction dictates both how quickly the infection
is cleared and the severity of the pathology associated with th

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