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Why Serological Responses during Cystitis are Limited.

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Date
2016-02-14
Authors
Choi, Hae Woong
Abraham, Soman N
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Abstract
The high frequency of urinary tract infections (UTIs), some of which appear to be endogenous relapses rather than reinfections by new isolates, point to defects in the host's memory immune response. It has been known for many decades that, whereas kidney infections evoked an antibody response to the infecting bacteria, infections limited to the bladder failed to do so. We have identified the existence of a broadly immunosuppressive transcriptional program associated with the bladder, but not the kidneys, during infection of the urinary tract that is dependent on bladder mast cells. This involves the localized secretion of IL-10 and results in the suppression of humoral immune responses in the bladder. Mast cell-mediated immune suppression could suggest a role for these cells in critically balancing the needs to clear infections with the imperative to prevent harmful immune reactions in the host.
Type
Journal article
Subject
cystitis
defects in memory response
mast cells
recurrent UTI
serology
Permalink
https://hdl.handle.net/10161/12469
Published Version (Please cite this version)
10.3390/pathogens5010019
Publication Info
Choi, Hae Woong; & Abraham, Soman N (2016). Why Serological Responses during Cystitis are Limited. Pathogens, 5(1). 10.3390/pathogens5010019. Retrieved from https://hdl.handle.net/10161/12469.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Abraham

Soman Ninan Abraham

Grace Kerby Distinguished Professor of Pathology
The Abraham laboratory is interested in developing innovative approaches for curbing microbial infections through the study of the molecular interactions occurring between pathogenic bacteria and prominent immune and epithelial cells. We believe that there is a significant amount of crosstalk occurring between bacteria and host cells during infection and that the outcome of this interaction dictates both how quickly the infection is cleared and the severity of the pathology associated with th
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