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Why Serological Responses during Cystitis are Limited.

dc.contributor.author Choi, Hae Woong
dc.contributor.author Abraham, Soman N
dc.coverage.spatial Switzerland
dc.date.accessioned 2016-07-15T15:33:38Z
dc.date.issued 2016-02-14
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26907352
dc.identifier pathogens5010019
dc.identifier.uri https://hdl.handle.net/10161/12469
dc.description.abstract The high frequency of urinary tract infections (UTIs), some of which appear to be endogenous relapses rather than reinfections by new isolates, point to defects in the host's memory immune response. It has been known for many decades that, whereas kidney infections evoked an antibody response to the infecting bacteria, infections limited to the bladder failed to do so. We have identified the existence of a broadly immunosuppressive transcriptional program associated with the bladder, but not the kidneys, during infection of the urinary tract that is dependent on bladder mast cells. This involves the localized secretion of IL-10 and results in the suppression of humoral immune responses in the bladder. Mast cell-mediated immune suppression could suggest a role for these cells in critically balancing the needs to clear infections with the imperative to prevent harmful immune reactions in the host.
dc.language eng
dc.publisher MDPI AG
dc.relation.ispartof Pathogens
dc.relation.isversionof 10.3390/pathogens5010019
dc.subject cystitis
dc.subject defects in memory response
dc.subject mast cells
dc.subject recurrent UTI
dc.subject serology
dc.title Why Serological Responses during Cystitis are Limited.
dc.type Journal article
duke.contributor.id Choi, Hae Woong|0479453
duke.contributor.id Abraham, Soman N|0200010
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26907352
pubs.issue 1
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 5


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