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Extended-release ranolazine: critical evaluation of its use in stable angina.

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Date
2011
Authors
Truffa, Adriano Am
Newby, L Kristin
Melloni, Chiara
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Abstract
Coronary heart disease is the major cause of morbidity and mortality throughout the world, and is responsible for approximately one of every six deaths in the US. Angina pectoris is a clinical syndrome characterized by discomfort, typically in the chest, neck, chin, or left arm, induced by physical exertion, emotional stress, or cold, and relieved by rest or nitroglycerin. The main goals of treatment of stable angina pectoris are to improve quality of life by reducing the severity and/or frequency of symptoms, to increase functional capacity, and to improve prognosis. Ranolazine is a recently developed antianginal with unique methods of action. In this paper, we review the pharmacology of ranolazine, clinical trials supporting its approval for clinical use, and studies of its quality of life benefits. We conclude that ranolazine has been shown to be a reasonable and safe option for patients who have refractory ischemic symptoms despite the use of standard medications (for example, nitrates, beta-adrenergic receptor antagonists, and calcium channel antagonists) for treatment of anginal symptoms, and also provides a modestly improved quality of life.
Type
Journal article
Subject
angina
coronary heart disease
ranolazine
treatment
Acetanilides
Angina, Stable
Animals
Cardiovascular Agents
Delayed-Action Preparations
Humans
Piperazines
Quality of Life
Ranolazine
Treatment Outcome
Permalink
https://hdl.handle.net/10161/12500
Published Version (Please cite this version)
10.2147/VHRM.S15560
Publication Info
Truffa, Adriano Am; Newby, L Kristin; & Melloni, Chiara (2011). Extended-release ranolazine: critical evaluation of its use in stable angina. Vasc Health Risk Manag, 7. pp. 535-539. 10.2147/VHRM.S15560. Retrieved from https://hdl.handle.net/10161/12500.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Melloni

Chiara Melloni

Adjunct Associate Professor in the Department of Medicine
Newby

Laura Kristin Newby

Professor of Medicine
Research Description General Focus: Clinical investigation the process and treatment of acute and chronic coronary artery disease and systems issues for delivery of care to patients with these illnesses. Particular interests include management of patients with chest pain and unstable angina, evaluation of the use of biochemical markers other than CK-MB for diagnosis and risk stratification in these patients, issues related to coronary artery disease in women, and systems issues
Alphabetical list of authors with Scholars@Duke profiles.
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