Extended-release ranolazine: critical evaluation of its use in stable angina.
Abstract
Coronary heart disease is the major cause of morbidity and mortality throughout the
world, and is responsible for approximately one of every six deaths in the US. Angina
pectoris is a clinical syndrome characterized by discomfort, typically in the chest,
neck, chin, or left arm, induced by physical exertion, emotional stress, or cold,
and relieved by rest or nitroglycerin. The main goals of treatment of stable angina
pectoris are to improve quality of life by reducing the severity and/or frequency
of symptoms, to increase functional capacity, and to improve prognosis. Ranolazine
is a recently developed antianginal with unique methods of action. In this paper,
we review the pharmacology of ranolazine, clinical trials supporting its approval
for clinical use, and studies of its quality of life benefits. We conclude that ranolazine
has been shown to be a reasonable and safe option for patients who have refractory
ischemic symptoms despite the use of standard medications (for example, nitrates,
beta-adrenergic receptor antagonists, and calcium channel antagonists) for treatment
of anginal symptoms, and also provides a modestly improved quality of life.
Type
Journal articleSubject
anginacoronary heart disease
ranolazine
treatment
Acetanilides
Angina, Stable
Animals
Cardiovascular Agents
Delayed-Action Preparations
Humans
Piperazines
Quality of Life
Ranolazine
Treatment Outcome
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https://hdl.handle.net/10161/12500Published Version (Please cite this version)
10.2147/VHRM.S15560Publication Info
Truffa, Adriano Am; Newby, L Kristin; & Melloni, Chiara (2011). Extended-release ranolazine: critical evaluation of its use in stable angina. Vasc Health Risk Manag, 7. pp. 535-539. 10.2147/VHRM.S15560. Retrieved from https://hdl.handle.net/10161/12500.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Chiara Melloni
Adjunct Associate Professor in the Department of Medicine
Laura Kristin Newby
Professor of Medicine
Research Description General Focus: Clinical investigation the process and treatment
of acute and chronic coronary artery disease and systems issues for delivery of care
to patients with these illnesses. Particular interests include management of patients
with chest pain and unstable angina, evaluation of the use of biochemical markers
other than CK-MB for diagnosis and risk stratification in these patients, issues related
to coronary artery disease in women, and systems issues
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