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High-speed label-free functional photoacoustic microscopy of mouse brain in action.

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Date
2015-05
Authors
Yao, Junjie
Wang, Lidai
Yang, Joon-Mo
Maslov, Konstantin I
Wong, Terence TW
Li, Lei
Huang, Chih-Hsien
Zou, Jun
Wang, Lihong V
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Abstract
We present fast functional photoacoustic microscopy (PAM) for three-dimensional high-resolution, high-speed imaging of the mouse brain, complementary to other imaging modalities. We implemented a single-wavelength pulse-width-based method with a one-dimensional imaging rate of 100 kHz to image blood oxygenation with capillary-level resolution. We applied PAM to image the vascular morphology, blood oxygenation, blood flow and oxygen metabolism in both resting and stimulated states in the mouse brain.
Type
Journal article
Subject
Animals
Blood Flow Velocity
Brain
Electric Stimulation
Female
Mice
Microscopy
Photoacoustic Techniques
Reproducibility of Results
Permalink
https://hdl.handle.net/10161/12773
Published Version (Please cite this version)
10.1038/nmeth.3336
Publication Info
Yao, Junjie; Wang, Lidai; Yang, Joon-Mo; Maslov, Konstantin I; Wong, Terence TW; Li, Lei; ... Wang, Lihong V (2015). High-speed label-free functional photoacoustic microscopy of mouse brain in action. Nat Methods, 12(5). pp. 407-410. 10.1038/nmeth.3336. Retrieved from https://hdl.handle.net/10161/12773.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Yao

Junjie Yao

Associate Professor of Biomedical Engineering
Our mission at PI-Lab is to develop state-of-the-art photoacoustic tomography (PAT) technologies and translate PAT advances into diagnostic and therapeutic applications, especially in functional brain imaging and early cancer theranostics. PAT is the most sensitive modality for imaging rich optical absorption contrast over a wide range of spatial scales at high speed, and is one of the fastest growing biomedical imaging technologies. Using numerous endogenous and exogenous contrasts, PAT can
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