PENTAZOCINE VERSUS PENTAZOCINE WITH RECTAL DICLOFENAC FOR POSTOPERATIVE PAIN RELIEF AFTER CESAREAN SECTION- A DOUBLE BLIND RANDOMIZED PLACEBO CONTROLLED TRIAL IN A LOW RESOURCE AREA.
Abstract
BACKGROUND: The unimodal approach of using pentazocine as post-cesarean section pain
relief is inadequate, hence the need for a safer, easily available and more effective
multimodal approach. AIM: To evaluate the effectiveness of rectal diclofenac combined
with intramuscular pentazocine for postoperative pain following cesarean section.
METHODS: In this double blind clinical trial, 130 pregnant women scheduled for cesarean
section under spinal anesthesia were randomly assigned to two groups. Group A received
100mg diclofenac suppository and group B received placebo suppository immediately
following surgery, 12 and 24h later. Both groups also received intramuscular pentazocine
30mg immediately following surgery and 6 hourly postoperatively in the first 24 h.
Postoperative pain was assessed by visual analogue scale at end of surgery and 2,
12 and 24 h after surgery. Patient satisfaction scores were also assessed. RESULTS:
One hundred and sixteen patients completed the study. Combining diclofenac and pentazocine
had statistically significant reduction in pain intensity at 2, 12, and 24 hours postoperatively
compared to pentazocine alone (p <0.05). No significant side effects were noted in
both groups. The combined group also had significantly better patient satisfaction
scores. CONCLUSION: The addition of diclofenac suppository to intramuscular pentazocine
provides better pain relief after cesarean section and increased patient satisfaction.
Type
Journal articleSubject
AdultAnalgesics, Opioid
Anti-Inflammatory Agents, Non-Steroidal
Diclofenac
Double-Blind Method
Female
Health Resources
Humans
Pain, Postoperative
Patient Satisfaction
Pentazocine
Pregnancy
Suppositories
Visual Analog Scale
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Show full item recordScholars@Duke
Adeyemi John Olufolabi
Professor of Anesthesiology
My interests include obstetric and gynecological anesthesia research. This includes
the use of opioids in obstetric population. I also have an interest in the management
of the difficult airway in general anesthesia and in the Obstetric population. More
recently, I have been engaged in global health and the role of anesthesia in resolving
the disparity gap. I have a particular interest in anesthesia in sub-sahara Africa
and have been involved in capacity building, research and educat

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