Advancing cardiovascular tissue engineering.
Abstract
Cardiovascular tissue engineering offers the promise of biologically based repair
of injured and damaged blood vessels, valves, and cardiac tissue. Major advances in
cardiovascular tissue engineering over the past few years involve improved methods
to promote the establishment and differentiation of induced pluripotent stem cells
(iPSCs), scaffolds from decellularized tissue that may produce more highly differentiated
tissues and advance clinical translation, improved methods to promote vascularization,
and novel in vitro microphysiological systems to model normal and diseased tissue
function. iPSC technology holds great promise, but robust methods are needed to further
promote differentiation. Differentiation can be further enhanced with chemical, electrical,
or mechanical stimuli.
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https://hdl.handle.net/10161/12994Published Version (Please cite this version)
10.12688/f1000research.8237.1Publication Info
Truskey, George A (2016). Advancing cardiovascular tissue engineering. F1000Res, 5. 10.12688/f1000research.8237.1. Retrieved from https://hdl.handle.net/10161/12994.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
George A. Truskey
R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering
My research interests focus upon the effect of physical forces on the function of
vascular cells and skeletal muscle, cell adhesion, and the design of engineered tissues.
Current research projects examine the effect of endothelial cell senescence upon
permeability to macromolecules and the response to fluid shear stress, the development
of microphysiological blood vessels and muscles for evaluation of drug toxicity and
the design of engineered endothelialized blood vessels and skelet

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