Inhibition, Not Excitation, Drives Rhythmic Whisking.
Repository Usage Stats
Sniffing and whisking typify the exploratory behavior of rodents. These actions involve separate oscillators in the medulla, located respectively in the pre-Bötzinger complex (preBötC) and the vibrissa-related region of the intermediate reticular formation (vIRt). We examine how these oscillators synergize to control sniffing and whisking. We find that the vIRt contains glycinergic/GABAergic cells that rhythmically inhibit vibrissa facial motoneurons. As a basis for the entrainment of whisking by breathing, but not vice versa, we provide evidence for unidirectional connections from the preBötC to the vIRt. The preBötC further contributes to the control of the mystacial pad. Lastly, we show that bilateral synchrony of whisking relies on the respiratory rhythm, consistent with commissural connections between preBötC cells. These data yield a putative circuit in which the preBötC acts as a master clock for the synchronization of vibrissa, pad, and snout movements, as well as for the bilateral synchronization of whisking.
Published Version (Please cite this version)10.1016/j.neuron.2016.03.007
Publication InfoDeschênes, M; Takatoh, J; Kurnikova, A; Moore, JD; Demers, M; Elbaz, M; ... Kleinfeld, D (2016). Inhibition, Not Excitation, Drives Rhythmic Whisking. Neuron, 90(2). pp. 374-387. 10.1016/j.neuron.2016.03.007. Retrieved from http://hdl.handle.net/10161/13003.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
More InfoShow full item record
Morris N. Broad Distinguished Professor
My lab studies neural circuit basis of sensory perception and motor action.Specifically we are interested in determining functions as well as mapping the meso-scale connectivity of neural circuits involved in (1) voluntary movements; (2) touch and pain sensation; and (3) social interactions. We use a combination of genetic, viral, electrophysiology, and in vivo imaging (in free-moving animals) techniques to study these questions.