Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation.
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Silver nanoparticles (AgNPs) have been increasingly commercialized and their release into the environment is imminent. Toxicity of AgNP has been studied with a wide spectrum of organisms, yet the mechanism of toxicity remains largely unknown. This study systematically compared toxicity of 10 AgNPs of different particle diameters and coatings to Japanese medaka (Oryzias latipes) larvae to understand how characteristics of AgNP relate to toxicity. Dissolution of AgNPs was largely dependent on particle size, but their aggregation behavior and toxicity were more dependent on coating materials. 96 h lethal concentration 50% (LC50) values correlated with AgNP aggregate size rather than size of individual nanoparticles. Of the AgNPs studied, the dissolved Ag concentration in the test suspensions did not account for all of the observed toxicity, indicating the role of NP-specific characteristics in resultant toxicity. Exposure to AgNP led to decrease of sodium concentration in the tissue and increased expression of Na(+)/K(+ )ATPase. Gene expression patterns also suggested that toxicity was related to disruption of sodium regulation and not to oxidative stress.
Published Version (Please cite this version)10.1080/17435390.2016.1206150
Publication InfoChernick, Melissa; Chilkoti, Ashutosh; Dong, Wu; Hinton, David E; Kwok, KW; Liu, J; ... Wiesner, Mark (2016). Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation. Nanotoxicology, 10(9). pp. 1306-1317. 10.1080/17435390.2016.1206150. Retrieved from http://hdl.handle.net/10161/13016.
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Alan L. Kaganov Professor of Biomedical Engineering
Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University. My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic bio
Nicholas Professor of Environmental Quality
The Hinton laboratory focuses on mechanistic toxicity in all life stages of small, aquarium model fish and in selected species with particular environmental relevance (freshwater and marine). With the latter, investigations focus on stressor responses and include follow up studies after oil spills. Studies with the laboratory model fish take advantage of the compressed life cycle to improve understanding of organellar, cellular and tissues responses that arise after exposure and follow either a
James B. Duke Professor of Civil and Environmental Engineering
Wiesner's research interests include membrane processes, nanostructured materials, transport and fate of nanomaterials in the environment, colloidal and interfacial processes, and environmental systems analysis.
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