dc.contributor.author |
Chernick, Melissa |
|
dc.contributor.author |
Chilkoti, Ashutosh |
|
dc.contributor.author |
Dong, Wu |
|
dc.contributor.author |
Hinton, David E |
|
dc.contributor.author |
Kwok, KW |
|
dc.contributor.author |
Liu, J |
|
dc.contributor.author |
Marinakos, Stella |
|
dc.contributor.author |
Wiesner, Mark |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2016-11-22T14:56:46Z |
|
dc.date.issued |
2016-11 |
|
dc.identifier |
http://www.ncbi.nlm.nih.gov/pubmed/27345576 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/13016 |
|
dc.description.abstract |
Silver nanoparticles (AgNPs) have been increasingly commercialized and their release
into the environment is imminent. Toxicity of AgNP has been studied with a wide spectrum
of organisms, yet the mechanism of toxicity remains largely unknown. This study systematically
compared toxicity of 10 AgNPs of different particle diameters and coatings to Japanese
medaka (Oryzias latipes) larvae to understand how characteristics of AgNP relate to
toxicity. Dissolution of AgNPs was largely dependent on particle size, but their aggregation
behavior and toxicity were more dependent on coating materials. 96 h lethal concentration
50% (LC50) values correlated with AgNP aggregate size rather than size of individual
nanoparticles. Of the AgNPs studied, the dissolved Ag concentration in the test suspensions
did not account for all of the observed toxicity, indicating the role of NP-specific
characteristics in resultant toxicity. Exposure to AgNP led to decrease of sodium
concentration in the tissue and increased expression of Na(+)/K(+ )ATPase. Gene expression
patterns also suggested that toxicity was related to disruption of sodium regulation
and not to oxidative stress.
|
|
dc.language |
eng |
|
dc.relation.ispartof |
Nanotoxicology |
|
dc.relation.isversionof |
10.1080/17435390.2016.1206150 |
|
dc.subject |
Coating |
|
dc.subject |
Oryzias latipes |
|
dc.subject |
nanosilver |
|
dc.subject |
oxidative stress |
|
dc.subject |
particle distribution |
|
dc.title |
Silver nanoparticle toxicity is related to coating materials and disruption of sodium
concentration regulation.
|
|
dc.type |
Journal article |
|
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/27345576 |
|
pubs.begin-page |
1306 |
|
pubs.end-page |
1317 |
|
pubs.issue |
9 |
|
pubs.organisational-group |
Biomedical Engineering |
|
pubs.organisational-group |
Chemistry |
|
pubs.organisational-group |
Civil and Environmental Engineering |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Cancer Institute |
|
pubs.organisational-group |
Duke Science & Society |
|
pubs.organisational-group |
Earth and Ocean Sciences |
|
pubs.organisational-group |
Environmental Sciences and Policy |
|
pubs.organisational-group |
Initiatives |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Institutes and Provost's Academic Units |
|
pubs.organisational-group |
Nicholas School of the Environment |
|
pubs.organisational-group |
Pratt School of Engineering |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
Staff |
|
pubs.organisational-group |
Trinity College of Arts & Sciences |
|
pubs.publication-status |
Published |
|
pubs.volume |
10 |
|
dc.identifier.eissn |
1743-5404 |
|