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Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation.

dc.contributor.author Chernick, Melissa
dc.contributor.author Chilkoti, Ashutosh
dc.contributor.author Dong, Wu
dc.contributor.author Hinton, David E
dc.contributor.author Kwok, KW
dc.contributor.author Liu, J
dc.contributor.author Marinakos, Stella
dc.contributor.author Wiesner, Mark
dc.coverage.spatial England
dc.date.accessioned 2016-11-22T14:56:46Z
dc.date.issued 2016-11
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/27345576
dc.identifier.uri http://hdl.handle.net/10161/13016
dc.description.abstract Silver nanoparticles (AgNPs) have been increasingly commercialized and their release into the environment is imminent. Toxicity of AgNP has been studied with a wide spectrum of organisms, yet the mechanism of toxicity remains largely unknown. This study systematically compared toxicity of 10 AgNPs of different particle diameters and coatings to Japanese medaka (Oryzias latipes) larvae to understand how characteristics of AgNP relate to toxicity. Dissolution of AgNPs was largely dependent on particle size, but their aggregation behavior and toxicity were more dependent on coating materials. 96 h lethal concentration 50% (LC50) values correlated with AgNP aggregate size rather than size of individual nanoparticles. Of the AgNPs studied, the dissolved Ag concentration in the test suspensions did not account for all of the observed toxicity, indicating the role of NP-specific characteristics in resultant toxicity. Exposure to AgNP led to decrease of sodium concentration in the tissue and increased expression of Na(+)/K(+ )ATPase. Gene expression patterns also suggested that toxicity was related to disruption of sodium regulation and not to oxidative stress.
dc.language eng
dc.relation.ispartof Nanotoxicology
dc.relation.isversionof 10.1080/17435390.2016.1206150
dc.subject Coating
dc.subject Oryzias latipes
dc.subject nanosilver
dc.subject oxidative stress
dc.subject particle distribution
dc.title Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/27345576
pubs.begin-page 1306
pubs.end-page 1317
pubs.issue 9
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Chemistry
pubs.organisational-group Civil and Environmental Engineering
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Science & Society
pubs.organisational-group Earth and Ocean Sciences
pubs.organisational-group Environmental Sciences and Policy
pubs.organisational-group Initiatives
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Nicholas School of the Environment
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group Staff
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 10
dc.identifier.eissn 1743-5404


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