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Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.

dc.contributor.author Antonsen, BT
dc.contributor.author Jiang, Y
dc.contributor.author Johnson, G Allan
dc.contributor.author Leergaard, TB
dc.contributor.author Nguyen, HP
dc.contributor.author Qu, H
dc.contributor.author Sijbers, J
dc.contributor.author Veraart, J
dc.contributor.author von Hörsten, S
dc.coverage.spatial Germany
dc.date.accessioned 2016-12-01T19:09:58Z
dc.date.issued 2013-05
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/22618438
dc.identifier.uri http://hdl.handle.net/10161/13090
dc.description.abstract Rodent models of Huntington disease (HD) are valuable tools for investigating HD pathophysiology and evaluating new therapeutic approaches. Non-invasive characterization of HD-related phenotype changes is important for monitoring progression of pathological processes and possible effects of interventions. The first transgenic rat model for HD exhibits progressive late-onset affective, cognitive, and motor impairments, as well as neuropathological features reflecting observations from HD patients. In this report, we contribute to the anatomical phenotyping of this model by comparing high-resolution ex vivo DTI measurements obtained in aged transgenic HD rats and wild-type controls. By region of interest analysis supplemented by voxel-based statistics, we find little evidence of atrophy in basal ganglia regions, but demonstrate altered DTI measurements in the dorsal and ventral striatum, globus pallidus, entopeduncular nucleus, substantia nigra, and hippocampus. These changes are largely compatible with DTI findings in preclinical and clinical HD patients. We confirm earlier reports that HD rats express a moderate neuropathological phenotype, and provide evidence of altered DTI measures in specific HD-related brain regions, in the absence of pronounced morphometric changes.
dc.language eng
dc.relation.ispartof Brain Struct Funct
dc.relation.isversionof 10.1007/s00429-012-0427-0
dc.subject Aging
dc.subject Animals
dc.subject Atrophy
dc.subject Brain
dc.subject Diffusion Tensor Imaging
dc.subject Disease Models, Animal
dc.subject Humans
dc.subject Huntingtin Protein
dc.subject Huntington Disease
dc.subject Image Processing, Computer-Assisted
dc.subject Magnetic Resonance Imaging
dc.subject Nerve Tissue Proteins
dc.subject Rats
dc.subject Rats, Transgenic
dc.subject Trinucleotide Repeat Expansion
dc.title Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/22618438
pubs.begin-page 767
pubs.end-page 778
pubs.issue 3
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Physics
pubs.organisational-group Radiology
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 218
dc.identifier.eissn 1863-2661


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